Results 61 to 70 of about 16,047,275 (319)
Technological and Economic Development of Economy, 2022 Infrastructure development is seen as an essential tool for boosting economic growth. Infrastructure is funded under various programs to contribute to economic growth, and reduce regional disparities.
Alma Mačiulytė-Šniukienė +2 more
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
ASEAN Regional Integration: The Philippines' domestic constraints to Physical connectivity
Jurnal Studi Pemerintahan, 2023 The ASEAN Master Plans for ASEAN Connectivity pursue the easement on the flow of goods, services, and people in the region as it endeavors to create a globally competitive single market and production base.
Tobit Abao, Hazel Jovita
doaj +1 more source
Digital Transformation: Infrastructure Sharing in Latin America and the Caribbean
, 2020 Access to digital infrastructure is key to socioeconomic development. Nevertheless, more than 60 percent of the population of Latin America and the Caribbean lack access to quality digital infrastructure.
Inter-American Development Bank
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Infrastructure for Development - Vol. 3, No. 1: How to Modernize the Rail System in Buenos Aires
, 2019 Through this series of case studies, the IDB\u27s Department of Infrastructure and Energy seeks to share its work in the region, the problems addressed, the challenges in implementing its projects, and the lessons learned from them. “How to modernize the
Inter-American Development Bank
core +1 more source
Re-Infrastructuring for eHealth: Dealing with Turns in Infrastructure Development [PDF]
Computer Supported Cooperative Work (CSCW), 2017 In this paper, we examine infrastructuring in the context of developing national, public eHealth services in Norway. Specifically, we analyze the work of a project team engaged in the design and development of new web-based capabilities for communication between citizens and primary healthcare practitioners.
Miria Grisot, Polyxeni Vassilakopoulou
openaire +5 more sources
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
2023 Joint Report on Multilateral Development Banks Climate Finance [PDF]
This 13th edition of the Joint Report on Multilateral Development Banks Climate Finance is an overview of climate finance committed in 2023 by the African Development Bank (AfDB), the Asian Development Bank (ADB), the Asian Infrastructure Investment Bank
Inter-American Development Bank
core +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source