Results 91 to 100 of about 759,358 (315)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Design and application of a Luer-lock tip to Luer-slip tip conversion device for Luer-lock syringes (一种螺旋口注射器的螺旋口转直口转换装置的设计与应用)

open access: yes中西医结合护理
Syringe is a common clinical medical appliance, which plays an important role in liquid allocation, infusion and nasal feeding. Syringes are mainly divided into Luer-lock syringes and Luer-slip syringes.
ZHENG Ou (郑鸥)   +3 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Potential uses of botanical extracts of Larrea and Grindelia in organic agriculture: Effects on soil properties and functional traits relative to growth

open access: yesEcología Austral
Biostimulants—including botanical extracts—are natural preparations that have no negative effects on environmental health or populations and improve soil health and plant growth.
Lucía C. Marino   +3 more
doaj   +1 more source

Anti-hyperglycemic Effect of Psidium guajava Leaf Infusion

open access: yesAlthea Medical Journal, 2015
Background: Prevalence of diabetes mellitus is estimated to increase annually. Numerous people use traditional medicine, such as the Poidium guajava leaf to prevent this disease.
Rizda Nurul Zartiana   +2 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

open access: yesFEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança   +2 more
wiley   +1 more source

Extended infusion versus intermittent infusion of imipenem in the treatment of ventilator-associated pneumonia

open access: yes, 2017
Mohamed M Ibrahim,1 Tarek Fouad Tammam,2 Mohy El Deen Ebaed,3 Hatem A Sarhan,4 Gamal F Gad,5 Amal K Hussein4 1Department of Clinical Pharmacy, Faculty of Pharmacy, Minia University, Minia, Egypt; 2Department of Anesthesia and Intensive Care, Faculty of ...
Sarhan HA   +5 more
core  

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

open access: yesFEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell   +2 more
wiley   +1 more source

Clinical Challenge: Standard Versus Extended Meropenem Infusion in Children

open access: yes
The management of Gram-negative bacterial infections poses a significant challenge due to the emergence of highly effective antibiotic-resistant mechanisms, leading to treatment failures, particularly among hospitalized children.
Kübra Aykaç   +5 more
core   +1 more source

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