Results 101 to 110 of about 165,534 (345)

Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden [PDF]

, 2010
Background It has traditionally been thought that the pathological accumulation of tau in Alzheimer's disease and other tauopathies facilitates neurodegeneration, which in turn leads to cognitive impairment.
A de Calignon, AD Mosnaim, Amelia G Johnson, B Reisberg, B Zhang, CA Dickey, CA Dickey, Chad A Dickey, Clara Kraft, Edwin J Weeber, EM Sigurdsson, Erin E Congdon, F van Bebber, HM Hassan, I Walter-Sack, J Lewis, Jason E Gestwicki, Jeffrey R Jones, John C O'Leary, John Koren, Jose F Abisambra, K Santacruz, Karen E Duff, Laura J Blair, M Necula, M Oz, Melinda Peters, MJ West, ML Smith, MP Mazanetz, Paul Marinec, Qingyou Li, RS Doody, S Deiana, S Taniguchi, TL Spires-Jones, TM Visarius, UK Jinwal, Umesh K Jinwal   +38 more
core   +6 more sources

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Heme Oxygenase-1 Expression Affects Murine Abdominal Aortic Aneurysm Progression. [PDF]

, 2016
Heme oxygenase-1 (HO-1), the rate-limiting enzyme in heme degradation, is a cytoprotective enzyme upregulated in the vasculature by increased flow and inflammatory stimuli.
Azuma, Junya, Dalman, Ronald L, Deng, Alicia C, Hsu, Mark, Kalish, Flora, Kayama, Yosuke, Maegdefessel, Lars, Morisawa, Takeshi, Spin, Joshua M, Stevenson, David K, Tsao, Philip S, Wallenstein, Matthew B, Wong, Ronald J, Zhao, Hui   +13 more
core   +2 more sources

Impact of Stress‐Induced Hyperglycemia on In‐Hospital Medical Complications in Patients With Acute Stroke: From a Large‐Scale Nationwide Longitudinal Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Aims This study aimed to explore the relationship between stress‐induced hyperglycemia (SIH) and in‐hospital medical complications in patients with acute stroke. Methods We enrolled 865,765 patients with acute stroke from the Chinese Stroke Center Alliance cohort.
Xintong Song, Yi Ju, Hongqiu Gu, Zhikai Zhu, Zixiao Li, Qian Zhang, Xingquan Zhao   +6 more
wiley   +1 more source

Comparing setup time and patient preferences for SCIg therapy: a head-to-head cross-sectional evaluation of two SC pumps

Future Science OA
Background This study compares the setup time and steps of two different subcutaneous infusion pumps using a 50 mL prefilled syringe (or PFS).Methods This cross-sectional time and motion assessment followed by a survey gathered patient setup time, number
Brent Rutland, Suzanne Strasters, Jasmin Bosshard   +2 more
doaj   +1 more source

Infusion of iloprost without a peristaltic pump: Safety and tolerability

Italian Journal of Medicine, 2013
Introduction: Iloprost is a potent prostacyclin (PGI2) analogue that is effective in the treatment of peripheral arterial disease, vasculitis, pulmonary hypertension, and secondary Raynaud’s phenomenon.
Paola Faggioli, Leopoldo Giani, Antonino Mazzone   +2 more
doaj   +1 more source

Prediction of Myasthenia Gravis Worsening: A Machine Learning Algorithm Using Wearables and Patient‐Reported Measures

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare disorder characterized by fluctuating muscle weakness with potential life‐threatening crises. Timely interventions may be delayed by limited access to care and fragmented documentation. Our objective was to develop predictive algorithms for MG deterioration using multimodal telemedicine data ...
Maike Stein, Haoqi Sun, Sophie Lehnerer, Lea Gerischer, Maximilian Mönch, Christian Meisel, Andreas Meisel, Pushpa Narayanaswami   +7 more
wiley   +1 more source

Author response for "Improved Postprandial Glucose Control With Ultra Rapid Lispro Versus Lispro With Continuous Subcutaneous Insulin Infusion in Type 1 Diabetes: PRONTO‐Pump ‐2"

, 2021
Mark Warren, Bruce W. Bode, Jang Ik Cho, Rong Liu, Janet Tobian, Thomas A. Hardy, Farai Chigutsa, Moshe Phillip, Barry Horowitz, Debra A. Ignaut   +9 more
openalex   +1 more source

Olink Proteomics Analysis Reveals Heterogeneous Responses to FcRn Blockade in Anti‐AChR Antibody‐Positive Myasthenia Gravis: FGF‐19 as a Novel Biomarker

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to systematically observe the clinical manifestations, immune cell subsets, and dynamic changes in serological indicators in patients with myasthenia gravis (MG) before and after efgartigimod (EFG) treatment. Methods We analyzed the baseline data, laboratory parameters, and lymphocyte subset proportions in MG ...
Tiancheng Luo, Deyou Peng, Zhouao Zhang, Mingjin Yang, Xinyan Guo, Tianyu Ma, Xiaoyu Huang, Mingming Xu, Linlin Fu, Yong Zhang   +9 more
wiley   +1 more source

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source