Results 201 to 210 of about 135,337 (265)

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Case Report: Tocilizumab as time-limited induction therapy enabling steroid withdrawal and conventional maintenance in refractory cutaneous polyarteritis nodosa. [PDF]

Front Med (Lausanne)
Joo Hu KWK, Jaederlund F, Lohse F, Karsulovic C, Hojman L.   +4 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

First-in-human use of recombinant IL-7 to potentiate antigen-specific T cell therapy: a single patient case study. [PDF]

J Immunother Cancer
Bermack C, Singh S, Pei G, Patel SP, Wang L, Yee C.   +5 more
europepmc   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Age-related moderation of adjunctive psychotherapy and early life stress effects on depression symptom reductions following ketamine treatment: Initial insights from a large, naturalistic sample. [PDF]

J Affect Disord
Kosted R, Waddell A, Adolph K, Fonzo GA.
europepmc   +1 more source

Case Report: Treatment of refractory lung disease in systemic juvenile idiopathic arthritis with cyclophosphamide and rituximab combination therapy. [PDF]

Front Immunol
Freeman WJ, Rife EC, Cron RQ.
europepmc   +1 more source

Long-term relief of CRPS-associated limb dystonia with ketamine infusion. [PDF]

BMJ Case Rep
AlZahrani A, Weber-Adrian D, Ong MC.
europepmc   +1 more source

NK cell infusion is well-tolerated and shows preliminary efficacy in patients with recurrent hepatocellular carcinoma post-liver transplantation : a phase I trial. [PDF]

J Transl Med
Yang F, Gong Y, Zheng X, Ni B, Lu J, Chen X, Cheng J, Li P, Du C, Chen Y, Zhang Y, Yi S, Wang G, Zhang Q, Yang Y, Chen W.   +15 more
europepmc   +1 more source

Correction: Continuous versus intermittent vancomycin infusions in critically ill children with gram-positive bacterial infections: a randomized controlled trial. [PDF]

BMC Infect Dis
Wu Y, Liu S, Shi C, Zhang M, Chen J, Huang X, Cui X, Huang S, Fan J, Qu D, Meng L.   +10 more
europepmc   +1 more source