Results 81 to 90 of about 8,624 (207)

Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention

Nature Communications, 2017
BKM120 (Buparlisib) is one of the most advanced phosphoinositide 3-kinase (PI3K) inhibitors for the treatment of cancer, but it interferes as an off-target effect with microtubule polymerization.
Thomas Bohnacker, A. Prota, F. Beaufils, J. Burke, A. Melone, Alison J. Inglis, Denise Rageot, A. Sele, Vladimir Cmiljanović, Nataša Cmiljanović, K. Bargsten, A. Aher, A. Akhmanova, J. Díaz, D. Fabbro, M. Zvelebil, Roger L. Williams, M. Steinmetz, M. Wymann   +18 more
semanticscholar   +1 more source

Relational work with distressing voices mirroring experiences of discrimination and marginalisation: Three illustrative cases of an extended form of AVATAR therapy (AV‐EXT)

Psychology and Psychotherapy: Theory, Research and Practice, EarlyView.
Abstract Background For voice‐hearers from minoritised communities, voices may reflect interpersonal and societal discrimination, including experiences of feeling silenced or ‘voiceless’. AVATAR therapy is a relational approach involving facilitated dialogues between a voice‐hearer and a digital embodiment of their main distressing voice (the avatar ...
Thomas Ward, Hannah Ball, Alice Montague, Nikos Xanidis, Chanelle Myrie, Isobel Murcutt, Edward Oshodi, Clementine Edwards, Amy Hardy, Moya Clancy, Jeffrey McDonnell, Mar Rus‐Calafell, Hamish McLeod, Philippa Garety, Thomas Craig   +14 more
wiley   +1 more source

Hearing Norton Sound: community involvement in the design of a mixed methods community randomized trial in 15 Alaska Native communities

Research Involvement and Engagement, 2020
Plain English summary Community involvement is important in good research practice. We led a community-based study to improve early detection and treatment of childhood hearing loss in rural Alaska.
Samantha Kleindienst Robler, S. Meade Inglis, Joseph J. Gallo, Heather E. Parnell, Paul Ivanoff, Stephanie Ryan, Cole D. Jenson, Alexandra Ross, Alain Labrique, Nae-Yuh Wang, Susan D. Emmett   +10 more
doaj   +1 more source

Faith in the Marketplace: Christian Legal Narratives and the Refusal to Serve Gay Customers

Sociological Forum, EarlyView.
ABSTRACT In June 2023, the US Supreme Court in 303 Creative v. Elenis held that an anti‐discrimination statute could not force a Christian business owner to provide certain business services to gay people. The decision has created a slew of legal and social uncertainties, which require a deeper investigation of the contemporary conflict between the gay
Mantas Grigorovicius
wiley   +1 more source

Combinatorial Glycomic Analyses to Direct CAZyme Discovery for the Tailored Degradation of Canola Meal Non-Starch Dietary Polysaccharides

Microorganisms, 2020
Canola meal (CM), the protein-rich by-product of canola oil extraction, has shown promise as an alternative feedstuff and protein supplement in poultry diets, yet its use has been limited due to the abundance of plant cell wall fibre, specifically non ...
Kristin E. Low, Xiaohui Xing, Paul E. Moote, G. Douglas Inglis, Sivasankari Venketachalam, Michael G. Hahn, Marissa L. King, Catherine Y. Tétard-Jones, Darryl R. Jones, William G. T. Willats, Bogdan A. Slominski, D. Wade Abbott   +11 more
doaj   +1 more source

Acute cardiovascular changes following heat exposure during simulated shipboard firefighting

Experimental Physiology, EarlyView.
Abstract Like structural firefighting, shipboard firefighting requires extreme exertion. However, shipboard firefighting may be a unique cardiovascular stress as most sailors lack extensive firefighting experience and may complete significant work before reaching the fire scene.
Daniel K. Sweet, Elizabeth M. Lavoie, Hayden W. Hess, Stuart Inglis, Brian Monaco, J. Luke Pryor, Steven E. Reis, David Hostler   +7 more
wiley   +1 more source

Low‐threshold cutaneous mechanoreceptors on the foot sole have enhanced sensitivity when skin temperature is elevated

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic illustration of microneurography recordings used to examine the effects of local skin heating on cutaneous mechanoreceptor responses in the human foot (left panel). A microelectrode inserted into a peripheral nerve records single‐unit activity from tactile afferent fibres while controlled mechanical stimuli are applied ...
Erika E. Howe, Michael Apollinaro, Joanna Reeves, Christopher Nester, Leah R. Bent   +4 more
wiley   +1 more source

Removal of the cecum affects intestinal fermentation, enteric bacterial community structure, and acute colitis in mice

Gut microbes, 2018
The murine cecum is a major site of fermentation of dietary materials, and production of short chain fatty acids (SCFAs). To examine the role that the cecum plays in acute bacterial infection in mice, the cecum was surgically removed, and changes in ...
Kirsty Brown, D. W. Abbott, R. Uwiera, G. Inglis   +3 more
semanticscholar   +1 more source

Bringing a Wider Socioecological Lens to the Psychology of Poverty

Social Issues and Policy Review, Volume 20, Issue 1, December 2026.
ABSTRACT Poverty is a persistent social issue that policymakers have turned to psychology for help in addressing. This has spurred an upswing in research on the psychology of poverty over the past 15 years, leading to a maturing evidence base on how the conditions of resource scarcity and other forms of socioeconomic adversity shape decision‐making and
Jennifer Sheehy‐Skeffington, Julia Buzan, Iván Cano, Fiona tho Pesch, Jessica Rea   +4 more
wiley   +1 more source

Rendering transparency to ranking in educational assessment via Bayesian comparative judgement

Review of Education, Volume 14, Issue 2, August 2026.
Abstract Transparency in educational assessment has become an increasingly pressing concern, particularly in the aftermath of the pandemic, as institutions seek more equitable, robust and defensible methods of evaluating student work. Comparative judgement (CJ) has gained traction as a promising alternative to traditional rubric‐based marking. However,
Andy Gray, Stephen Lindsay, Jen Pearson, Tom Crick, Alma Rahat   +4 more
wiley   +1 more source