Results 161 to 170 of about 849,946 (335)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Comparable improvements in selective, but not sustained, attention in response to a multi-ingredient nootropic formulation when compared with caffeine. [PDF]

Eur J Nutr
Hearris MA, Langan-Evans C, Foo WL, Garrigan C, Starke L, Rendeiro C, Williams C, Jackson P, Morton JP.   +8 more
europepmc   +1 more source

Some of the Ingredients Spicing Up the Bitcoin Price: Covid, Inflation and War

Natividad Blasco, Pilar Corredor, Nerea Satrústegui   +2 more
openalex   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Adverse drug events from paediatric use of extemporaneously compounded medicines in community pharmacy settings: a scoping review. [PDF]

BMJ Paediatr Open
Li J, Buckley NA, Lee J, Cairns R.
europepmc   +1 more source

RIFM fragrance ingredient safety assessment, 1-cyclohexene-1-acetic acid, CAS Registry Number 18294-87-6

, 2019
A.M. Api, D. Belsito, D. Botelho, M. Bruze, G.A. Burton, J. Buschmann, M.L. Dagli, M. Date, W. Dekant, C. Deodhar, M. Francis, A.D. Fryer, L. Jones, K. Joshi, S. La Cava, A. Lapczynski, D.C. Liebler, D. O’Brien, A. Patel, T.M. Penning, G. Ritacco, J. Romine, N. Sadekar, D. Salvito, T.W. Schultz, I.G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura, S. Tsang   +29 more
openalex   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Updating our quantification of non-occupational pesticide exposure in agricultural settings: A revised algorithm for the Agricultural Health Study. [PDF]

Environ Adv
Xie S, Deziel NC, Josse PR, Madrigal JM, Parks CG, Sandler DP, Andreotti G, Ward MH, Hofmann JN, Freeman LEB, Friesen MC.   +10 more
europepmc   +1 more source

RIFM fragrance ingredient safety assessment, α-Methylbenzyl acetate, CAS Registry Number 93-92-5

, 2016
A.M. Api, D. Belsito, S.P. Bhatia, M. Bruze, Peter Calow, M.L. Dagli, W. Dekant, A D Fryer, L. Kromidas, S. La Cava, J. Lalko, A. Lapczynski, D.C. Liebler, V.T. Politano, G. Ritacco, D. Salvito, T. Wayne Schultz, J. Shen, I.G. Sipes, B. Wall, D.K. Wilcox   +20 more
openalex   +1 more source

<i>Salmonella</i> Contamination on Feed Ingredients and Formula Feeds and its Control Methods

, 2020
Takayuki Morita, Tetsuo Chihara
openalex   +2 more sources