Results 91 to 100 of about 149,229 (299)

CXCL3 Antagonism Reverses Systemic Antitumor Immune Memory Impairment Associated With High Tumor Burden and Sensitizes Anti‐PD‐1 Therapy

Advanced Science, EarlyView.
This study reveals that large tumors secrete more chemokine CXCL3, which recruits immunosuppressive neutrophils to the periphery, thereby impairing the activation and memory of systemic tumor‑reactive CD8+ T cells. CXCL3 antagonism restores systemic immune memory and enhances the antitumor efficacy of anti‑PD‑1 therapy, offering a potential strategy to
Ji Wang, Xinyu Tang, Zeju Li, Qi Qi, Chang Sun, Wen Sun, Weiya Zhang, Yue Yin, Ya Deng, Peiwen Ling, Yifan Xu, Guangshun Sun, Yi Ren, Hong Pan, Shui Wang, Wenbin Zhou   +15 more
wiley   +1 more source

Pain control following inguinal herniorrhaphy: current perspectives

, 2014
Martin F Bjurstrom,1,* Andrea L Nicol,2,* Parviz K Amid,3 David C Chen3 1Department of Anesthesiology, UCLA, Los Angeles, CA, USA; 2Department of Anesthesiology, University of Kansas, Kansas City, KS, USA; 3Department of Surgery, Lichtenstein Amid Hernia
Nicol AL, Bjurstrom MF, Chen DC, Amid PK
core  

Acoustically Activatable Drug‐Loaded Nanodroplets for Mechanochemical Therapy in Solid Tumors

Advanced Science, EarlyView.
Microfluidically fabricated drug‐loaded nanodroplets are sequentially activated by dual‐frequency ultrasound through acoustic droplet vaporization followed by bubble collapse, enabling spatially controlled drug release and mechanical tumor fractionation, resulting in synergistic mechanochemotherapy and prolonged survival.
Tiran Bercovici, Mike Bismuth, Meir Goldsmith, Dan Peer, Tali Ilovitsh   +4 more
wiley   +1 more source

A 5-year review of darning technique of inguinal hernia repair

Nigerian Journal of Surgery, 2015
Context: The Darning technique of inguinal hernia repair is a tissue-based technique with documented low recurrence rate in some parts of the world. Though practiced in our setting, little is documented on its outcome.
Olalekan O Olasehinde, Adewale O Adisa, Elugwaraonu A Agbakwuru, Amarachukwu C Etonyeaku, Oladapo A Kolawole, Arinze O Mosanya   +5 more
doaj   +1 more source

Comparison of Nationwide Volumes for Five Major Gastrointestinal Surgical Procedures in Japan: Implications From Publicly Available NCD and NDB Open Data

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Aim In Japan, the National Clinical Database (NCD), a clinician‐reported registry, and the National Database of Health Insurance Claims and Specific Health Checkups of Japan Open Data (NDB Open Data), an administrative claims database, are both widely used as nationwide surgical databases, but their consistency in capturing national surgical ...
Atomu Kiriyama, Masakazu Fujii, Toshimichi Asano, Satoshi Hirano   +3 more
wiley   +1 more source

Expanded Phenotype Associated With an Intronic PPP1R12A Variant: A Case Report and Literature Review

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Autosomal dominant PPP1R12A‐related genitourinary and/or brain malformation syndrome is a recently described multisystem disorder caused by loss‐of‐function variants in the protein phosphatase 1 regulatory subunit 12a (PPP1R12A) gene. To date, 22 affected individuals have been reported with variable brain malformations and genitourinary ...
Emily M. Bland, Amber Nakar Weinstein, Eric C. Kao, Xiaonan Zhao, Monika Weisz‐Hubshman   +4 more
wiley   +1 more source

Management of a giant inguinoscrotal hernia with an ulcerated base in a patient with cardiac disease

Journal of Surgical Case Reports, 2010
Giant inguinal herniae pose a surgical challenge, though not uncommon in the developing world they are a rare presentation in the UK. We present a patient with cardiac disease who presented with a giant inguino-scrotal hernia complicated by a bleeding ...
E Jane H Turner, Amar Malhas, Imran Chisti, Tayo Oke   +3 more
doaj  

Perfil demográfico, clínico e cirúrgico de uma série de 65 herniorrafias femorais realizadas no Hospital Florianópolis, em Florianópolis, Santa Catarina, entre julho de 1979 e agosto de 2003. [PDF]

, 2005
Trabalho de Conclusão de Curso - Universidade Federal de Santa Catarina. Curso de Medicina.
Reis, Ramon Castro.
core  

Evaluation of therapeutic effects of D‐limonene following orchiopexy in the rat model of cryptorchidism

Animal Models and Experimental Medicine, EarlyView.
D‐limonene supplementation enhances testicular recovery following orchiopexy in a rat model of bilateral cryptorchidism. Treatment with D‐limonene reduces oxidative stress (↓MDA, ↑SOD, ↑GPx, ↑TAC), downregulates pro‐apoptotic proteins (↓TNF‐α, ↓BAX, ↓Caspase‐3), and upregulates anti‐apoptotic Bcl‐2 expression.
Arman Norouzi‐Ghalehbala, Mohammadjavad Rezaei‐Varmaziar, Majid Taati, Ali Soleimanzadeh, Abbas Raisi, Farshid Davoodi, Amir Ali Shahbazfar   +6 more
wiley   +1 more source

Inguinal porokeratosis in a Japanese man

Dermatology Practical & Conceptual, 2013
Inguinal and genital porokeratosis is rare but seems to be more common in Asians. We report a case of a 69-year-old Japanese man with multiple lesions of porokeratosis in both inguinal regions.
Yuka Hayashi, Masahiko Ozeki, Sumiko Ishizaki, Mariko Fujibayashi, Yoshihiko Mitsuhashi, Miki Izumi, Masaru Tanaka   +6 more
doaj   +1 more source