Advanced Science, EarlyView.Parkinson's disease (PD) progression is aggravated by disrupted inter‐organelle contacts, which are influenced by mechanical forces. NanoMassage, 200 nm PEGylated black phosphorus nanosheets, deliver targeted mechanical stimulation to neural cells.
Tianqi Li +12 more
wiley +1 more source
A mechanistic model for smallpox transmission via inhaled aerosols inside respiratory pathways [PDF]
arXivInvestigations on airborne transmission of pathogens constitute a rapidly expanding field, primarily focused on understanding the expulsion patterns of respiratory particulates from infected hosts and their dispersion in confined spaces. Largely overlooked has been the crucial role of fluid dynamics in guiding inhaled virus-laden particulates within ...
arxiv
The Role of Diffusion Anoxia in the Production of Arrhythmias Following Inhalation of Carbon Dioxide [PDF]
, 1957 HAROLD F. CHASE, LOUIS J. HAMPTON
openalex +1 more source
Machine Learning‐Enabled Drug‐Induced Toxicity Prediction
Advanced Science, EarlyView.Unexpected toxicity accounts for 30% of drug development failures. This review highlights ML innovations in predicting drug‐induced toxicity, emphasizing comparative analyses, interpretable algorithms, and multi‐source data integration. It categorizes toxicity types, summarizes ML models, and organizes key databases, offering strategies to address ...
Changsen Bai +5 more
wiley +1 more source
Microfluidic Bioelectrical Impedance Drug Delivery Device for Patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease [PDF]
arXivInhalers with corticosteroids and muscle relaxants are prescribed by pulmonologists to mitigate bronchospasms that happen due to tightening of the chest. An adhesive patch attached to a patient with chronic obstructive pulmonary disease can relieve episodes of bronchospasms in the event the prescribed inhaler is not nearby.
arxiv
Operation for Scirrhus of the Left Breast Performed during the Inhalation of Sulphuric Aether [PDF]
W.P. Brookes
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An Agrin–YAP/TAZ Rigidity Sensing Module Drives EGFR‐Addicted Lung Tumorigenesis
Advanced Science, EarlyView.The study identifies agrin‐EGFR mechanotransduction as a critical driver of lung adenocarcinoma which enhances EGFR signaling through an integrin‐FAK‐actomyosin dependent positive feedback on YAP/TAZ ‐TEAD in response to matrix stiffness. Targeting this oncogenic loop through combinatorial treatments inhibits lung cancer due to agrin impairment.
Reza Bayat Mokhtari +20 more
wiley +1 more source
Safeguarding Smart Inhaler Devices and Patient Privacy in Respiratory Health Monitoring [PDF]
arXivThe rapid development of Internet of Things (IoT) technology has significantly impacted various market sectors. According to Li et al. (2024), an estimated 75 billion devices will be on the market in 2025. The healthcare industry is a target to improve patient care and ease healthcare provider burdens.
arxiv
DAPK3 is Essential for DBP‐Induced Autophagy of Mouse Leydig Cells
Advanced Science, EarlyView.This study has confirmed that death‐associated protein kinase 3 (DAPK3) is essential for dibutyl phthalate (DBP)‐induced autophagy of mouse Leydig cells, and is regulated by both transcription factor specific protein 2 (Sp2) and parkin RBR E3 ubiquitin‐protein ligase (PRKN), and melatonin can alleviate DBP‐induced autophagy of the cells.
Si Yang +4 more
wiley +1 more source
THE TREATMENT OF BRONCHIECTASIS BY THE CONTINUOUS INHALATION OF OXYGEN (STOKER'S METHOD). [PDF]
, 1909 W.P. Herringham
openalex +1 more source