Results 201 to 210 of about 259,936 (268)

Safety and pharmacokinetics of mosliciguat, a new, inhaled soluble guanylate cyclase activator, in healthy adult subjects

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mosliciguat (BAY 1237592), the first soluble guanylate cyclase (sGC) activator in a dry powder inhaler (DPI), could potentially treat pulmonary hypertension with a more targeted delivery than systemic sGC stimulators. We report safety and tolerability of mosliciguat in healthy men.
Johannes Nagelschmitz, Soundos Saleh, Sandra Ligges, Melanie Seidel‐Greven, Eva Becker‐Pelster, Sylvia M. Nikkho, Stefanie Boxnick, Wolfgang Timmer   +7 more
wiley   +1 more source

Safety and Efficacy of Nebulized Inhalation of Polymyxin B Sulfate for Carbapenem-Resistant Gram-Negative Bacterial Pneumonia: A Multi-Center, Prospective, Observational Study. [PDF]

Infect Drug Resist
Zhu M, Zhang J, Han Y, Zheng X, Xu Q, Chen Q, Chen S, Yao Y, Jiang R, Wu J, Zhou H, Lei S.   +11 more
europepmc   +1 more source

Impact of cumulative glucocorticoid exposure on vancomycin clearance in hospitalized children: A retrospective cohort study

British Journal of Clinical Pharmacology, EarlyView.
Prior glucocorticoid exposure is associated with modestly increased vancomycin clearance in hospitalized children, partly mediated by renal function and inflammation and may contribute to subtherapeutic early drug exposure. Abstract Introduction Augmented renal clearance (ARC) can lead to subtherapeutic vancomycin exposure in children.
Kouki Tomari, Ruud H. J. Verstegen, Cintia Cruz, Erin Chung, Aleena Azim, Shinya Ito, Tamorah R. Lewis   +6 more
wiley   +1 more source

<i>In vivo</i> lung microbiome alterations from burn pit emissions and/or sand inhalation exposures. [PDF]

Front Public Health
Frey JS, Grogg MW, Hoisington AJ, Wong BA, Mumy KL, Mauzy CA.   +5 more
europepmc   +1 more source

The quantification and epistemology of medicines use and polypharmacy tested in an observational study

British Journal of Clinical Pharmacology, EarlyView.
Definitions of ‘medicines use’ and ‘polypharmacy’ may refer to all medicines, regular long‐term medicines or another subset. Valid definitions of medicines use should incorporate type of use (long term, short course and as needed [PRN]), changes in use (start, stop and dose change) and a description of temporal examination (cross‐sectional or ...
Lorna Pairman, Paul Chin, Matthew Doogue
wiley   +1 more source

Effect of Preoperative Esketamine Nebulized Inhalation on Cough Reflex, Sedation, and Postoperative Sore Throat in Extubation of Surgical Patients: A Prospective, Double-Blind, Randomized Controlled Trial. [PDF]

Drug Des Devel Ther
Zhang ZQ, Yang R, Li JJ, Wang J, Chen SG, Mei B, Hu SH.   +6 more
europepmc   +1 more source

Characteristics of Adult Severe Uncontrolled Asthma Patients in Primary Care and Modifications in Prescribed Inhalation Treatments. [PDF]

J Asthma Allergy
Konradsen JR, Packham S, Vanfleteren LEGW, Syk J, Bossios A, Stridsman C.   +5 more
europepmc   +1 more source

Lipid accumulation and interstitial lung disease associated with amikacin liposomal inhalation suspension in patients with Mycobacterium avium complex lung disease: a single-center retrospective cohort study. [PDF]

BMC Pulm Med
Wakabayashi H, Isobe K, Hiruta N, Kasuya S, Sano A, Matsuzawa Y.   +5 more
europepmc   +1 more source

Therapeutic effects of oxygen inhalation for obstructive sleep apnea patients with high carotid body chemosensitivity. [PDF]

BMC Pulm Med
Wang HQ, Ping JQ, Xu JY, Zhu JY, Gao XY, Li HP, Kong C, Luo L.   +7 more
europepmc   +1 more source

A Phase 2 Study of the Safety and Tolerability of Treprostinil Palmitil Inhalation Powder in Patients With Pulmonary Hypertension Associated With Interstitial Lung Disease. [PDF]

Pulm Circ
Church C, Molina-Molina M, Arias-Guillén M, Muchmore P, Lavon BR, Backer J, Makulova N, Mistry B, Guo J, Wu J, Fahumy J, Teper A, Zhao PL, Mange KC, O'Brien G.   +14 more
europepmc   +1 more source