Results 271 to 280 of about 693,842 (409)

IFITM2 Modulates Endocytosis Maintaining Neural Stem Cells in Developing Neocortex

open access: yesAdvanced Science, EarlyView.
This study reveals IFITM2 as a key regulator of endocytosis in radial glial cells (RGCs) during brain development. IFITM2's YXXø motif and phosphoinositide‐binding residues (K82/K87) are essential for endosome formation. IFITM2 deficiency disrupts the embryonic cortical neurogenesis, revealing a conserved mechanism linking endocytic dynamics to neural ...
Yuqing Lv   +6 more
wiley   +1 more source

N‐acetyltransferase 10 promotes colon cancer progression by inhibiting ferroptosis through N4‐acetylation and stabilization of ferroptosis suppressor protein 1 (FSP1) mRNA

open access: yesCancer Communications, Volume 42, Issue 12, Page 1347-1366, December 2022., 2022
Abstract Background N‐acetyltransferase 10 (NAT10) is the only enzyme known to mediate the N4‐acetylcytidine (ac4C) modification of mRNA and is crucial for mRNA stability and translation efficiency. However, its role in cancer development and prognosis has not yet been explored.
Xiao Zheng   +8 more
wiley   +1 more source

Maximum Likelihood Estimation of the Prevalence of nonlethal Neoplasms [PDF]

open access: yes, 1982
Chameaud, J.   +3 more
core   +1 more source

Cardiac Slc25a49‐Mediated Energy Reprogramming Governs Doxorubicin‐Induced Cardiomyopathy through the G6P–AP‐1–Sln Axis

open access: yesAdvanced Science, EarlyView.
Doxorubicin‐induced cardiomyopathy involves mitochondrial energy metabolism dysfunction, exacerbated by cardiomyocyte‐specific Slc25a49 deficiency via oxidative phosphorylation (OXPHOS) suppression and glycolysis activation. The Slc25a49–glucose‐6‐phosphate (G6P)–activator protein‐1 (AP‐1) axis drives myocardial injury by upregulating Sln, disrupting ...
Sitong Wan   +16 more
wiley   +1 more source

Fragment Autoantigens Stimulated T‐Cell‐Immunotherapy (FAST) as a Fast Autologous Cancer Vaccine

open access: yesAdvanced Science, EarlyView.
A personalized whole tumor cell vaccine (FAST) is developed to address immunosuppressive tumor microenvironments and genomic instability‐driven heterogeneity. Irradiation and cryoablation‐treated tumor cells generate fragmented antigens (FAs) that activate broad‐spectrum antigen presentation via upregulated immunogenic cell death, MHC‐I, and damage ...
Yuan Li   +14 more
wiley   +1 more source

Flash‐Thermal Reduction of Graphene Oxide with Flexible Electronics Platform for Highly Sensitive Wearable Temperature Sensor

open access: yesAdvanced Electronic Materials, EarlyView.
In this study, by employing the flash‐thermal reduction (FTr) technique, the reduction degree of the graphene oxide (GO) with systematic analyses of conductivity and material stability is precisely adjusted. The optimized FTrGO‐based sensor exhibits exceptional flexibility, reversibility, high sensitivity (≈1.28% °C−1), excellent linearity (R2 ≈ 0.999),
Yeong Jun Yun   +8 more
wiley   +1 more source

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