Results 21 to 30 of about 137,595 (265)

Effects of haloperidol inhalation on MK-801- and memantine-induced locomotion in mice

Libyan Journal of Medicine, 2020
The administration of therapeutic agents is difficult in many patients, such as patients with post-operative delirium or dementia or patients with schizophrenia, who are upset in an emergency room.
Hiroshi Ueno, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Yu Takahashi, Yosuke Matsumoto, Motoi Okamoto, Takeshi Ishihara   +8 more
doaj   +1 more source

Emerging therapies for smoke inhalation injury: a review

Journal of Translational Medicine, 2020
Background Smoke inhalation injury increases overall burn mortality by up to 20 times. Current therapy remains supportive with a failure to identify an optimal or targeted treatment protocol for smoke inhalation injury.
Alexandra Mercel, Nick D. Tsihlis, Rob Maile, Melina R. Kibbe   +3 more
doaj   +1 more source

¿Son eficaces los corticoides inhalados en las exacerbaciones asmáticas? Evidentia praxis

Anales de Pediatría, 2021
Resumen: Se presenta un escenario clínico del que surge una pregunta clínica estructurada: en niños o adolescentes asmáticos con síntomas de exacerbación, ¿el uso de corticoides inhalados (de nueva instauración o aumento de dosis habitual) reduce el ...
Carlos Ochoa Sangrador, Álvaro Gimeno Díaz de Atauri, María Victoria Martínez Rubio   +2 more
doaj   +1 more source

Comparative Pharmacokinetic Assessment of Curcumin in Rats Following Intratracheal Instillation Versus Oral Administration: Concurrent Detection of Curcumin and Its Conjugates in Plasma by LC-MS/MS

Pharmaceutics
Objective: To establish and validate an LC-MS/MS method for the simultaneous determination of curcumin (CUR) as well as its glucuronide conjugate (COG) and sulfate conjugate (COS) in rat plasma.
Nan Li, Jinle Lou, Lingchao Wang, Wenpeng Zhang, Chunmei Jin, Xiaomei Zhuang   +5 more
doaj   +1 more source

Inhaler device, administration technique, and adherence to inhaled corticosteroids in patients with asthma [PDF]

Primary Care Respiratory Journal, 2011
To compare inhaled corticosteroid (ICS) inhaler type with user technique and ICS medication adherence among adults with asthma.We classified 270 adults into two groups by ICS device type: metered-dose inhaler (MDI) or dry powder inhaler (DPI). Inhaler technique was assessed using standardised checklists.
Angkana, Roy, Kayleigh, Battle, Linda, Lurslurchachai, Ethan A, Halm, Juan P, Wisnivesky   +4 more
openaire   +2 more sources

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Inhalation of itraconazole mitigates bleomycin-induced lung fibrosis via regulating SPP1 and C3 signaling pathway pivotal in the interaction between phagocytic macrophages and diseased fibroblasts

Journal of Translational Medicine
Background Idiopathic pulmonary fibrosis (IPF) stands as a significant contributor to global mortality rates. Presently, there exists a dearth of effective anti-fibrotic treatments for this condition.
Caizhe Pan, Hao Wei, Bi Chen, Lei Wu, Jiayao Song, Qing Zhang, Xinglong Wu, Guibai Liang, Wenhao Chen, Yingshuo Wang, Yicheng Xie   +10 more
doaj   +1 more source

Therapeutic Effects of Intratracheally Nebulized Carnosine-Loaded Liposomes on Lipopolysaccharide-Induced Acute Lung Injury

Pharmaceutics
Introduction: Acute lung injury (ALI) is characterized by severe inflammation and oxidative stress. However, effective pharmacological interventions for ALI remain limited.
Chao Fang, Lixin Xie, Daihan Xie, Jingting Yin, Shiji Zhang, Yiling Gan, Xiaodong Hou, Fanlei Kong, Yu Huo, Xiuli Liu   +9 more
doaj   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

How Intuitive Is the Administration of Pediatric Emergency Medication Devices for Parents? Objective Observation and Subjective Self-Assessment

Pharmacy
Background: to assess the intuitiveness of parents’ administration of pediatric emergency devices (inhalation, rectal, buccal, nasal, and auto-injector).
Ruth Melinda Müller, Birthe Herziger, Sarah Jeschke, Martina Patrizia Neininger, Thilo Bertsche, Astrid Bertsche   +5 more
doaj   +1 more source