Results 11 to 20 of about 23,865 (249)

Formaldehyde exposure induces differentiation of regulatory T cells via the NFAT-mediated T cell receptor signalling pathway in Yucatan minipigs

Scientific Reports, 2022
The use of minipigs (Sus scrofa) as a platform for toxicological and pharmacological research is well established. In the present study, we investigated the effect of formaldehyde (FA) exposure on helper T cell-mediated splenic immune responses in ...
Jeongsik Park, Goo-Hwa Kang, Youngkyu Kim, Ju Young Lee, Jeong Ah Song, Jeong Ho Hwang   +5 more
doaj   +1 more source

Coconut Oil Alleviates the Oxidative Stress-Mediated Inflammatory Response via Regulating the MAPK Pathway in Particulate Matter-Stimulated Alveolar Macrophages

Molecules, 2022
Exposure to particulate matter (PM) is related to various respiratory diseases, and this affects the respiratory immune system. Alveolar macrophages (AMs), which are defenders against pathogens, play a key role in respiratory inflammation through ...
Xinyu Chen, Dong Im Kim, Hi-Gyu Moon, Minchul Chu, Kyuhong Lee   +4 more
doaj   +1 more source

A Study on the Behavior Patterns of Liquid Aerosols Using Disinfectant Chloromethylisothiazolinone/Methylisothiazolinone Solution

Molecules, 2021
This study evaluates the behavioral characteristics of components (methylisothiazolinone (MIT) and chloromethylisothiazolinone (CMIT)) contained in disinfectant solutions when they convert to liquid aerosols.
Yong-Hyun Kim, Mi-Kyung Song, Kyuhong Lee   +2 more
doaj   +1 more source

Polypropylene nanoplastic exposure leads to lung inflammation through p38-mediated NF-κB pathway due to mitochondrial damage

Particle and Fibre Toxicology, 2023
Background Polypropylene (PP) is used in various products such as disposable containers, spoons, and automobile parts. The disposable masks used for COVID-19 prevention mainly comprise PP, and the disposal of such masks is concerning because of the ...
Jong-Hwan Woo, Hyeon Jin Seo, Jun-Young Lee, Iljung Lee, Kisoo Jeon, Bumseok Kim, Kyuhong Lee   +6 more
doaj   +1 more source

Pulmonary Toxicity of Polystyrene, Polypropylene, and Polyvinyl Chloride Microplastics in Mice

Molecules, 2022
Globally, plastics are used in various products. Concerns regarding the human body’s exposure to plastics and environmental pollution have increased with increased plastic use.
Isaac Kwabena Danso, Jong-Hwan Woo, Kyuhong Lee   +2 more
doaj   +1 more source

Toxicological evaluation of exhaust emissions from light-duty vehicles using different fuel alternatives in sub-freezing conditions

Particle and Fibre Toxicology, 2020
Background Emissions from road traffic are under constant discussion since they pose a major threat to human health despite the increasingly strict emission targets and regulations.
Henri Hakkarainen, Päivi Aakko-Saksa, Maija Sainio, Tuukka Ihantola, Teemu J. Rönkkö, Päivi Koponen, Topi Rönkkö, Pasi I. Jalava   +7 more
doaj   +1 more source

Lung-gut axis of microbiome alterations following co-exposure to ultrafine carbon black and ozone

Particle and Fibre Toxicology, 2023
Background Microbial dysbiosis is a potential mediator of air pollution-induced adverse outcomes. However, a systemic comparison of the lung and gut microbiome alterations and lung-gut axis following air pollution exposure is scant.
Md Habibul Hasan Mazumder, Jasleen Gandhi, Nairrita Majumder, Lei Wang, Robert Ian Cumming, Sydney Stradtman, Murugesan Velayutham, Quincy A. Hathaway, Jonathan Shannahan, Gangqing Hu, Timothy R. Nurkiewicz, Robert M. Tighe, Eric E. Kelley, Salik Hussain   +13 more
doaj   +1 more source

Maternal nano-titanium dioxide inhalation alters fetoplacental outcomes in a sexually dimorphic manner

Frontiers in Toxicology, 2023
The placenta plays a critical role in nutrient-waste exchange between the maternal and fetal circulations, thus functioning as an interface that profoundly impacts fetal growth and development. The placenta has long been considered an asexual organ, but,
Julie A. Griffith, Julie A. Griffith, Allison Dunn, Evan DeVallance, Evan DeVallance, Kallie J. Schafner, Kallie J. Schafner, Kevin J. Engles, Thomas P. Batchelor, Thomas P. Batchelor, William T. Goldsmith, William T. Goldsmith, Kimberley Wix, Kimberley Wix, Salik Hussain, Salik Hussain, Elizabeth C. Bowdridge, Elizabeth C. Bowdridge, Timothy R. Nurkiewicz, Timothy R. Nurkiewicz   +19 more
doaj   +1 more source

Relationship between Cytotoxicity and Surface Oxidation of Artificial Black Carbon

Nanomaterials, 2021
The lacking of laboratory black carbon (BC) samples have long challenged the corresponding toxicological research; furthermore, the toxicity tests of engineered carbon nanoparticles were unable to reflect atmospheric BC. As a simplified approach, we have
Yen Thi-Hoang Le, Jong-Sang Youn, Hi-Gyu Moon, Xin-Yu Chen, Dong-Im Kim, Hyun-Wook Cho, Kyu-Hong Lee, Ki-Joon Jeon   +7 more
doaj   +1 more source

Comparison of volatile organic compounds between cigarette smoke condensate (CSC) and extract (CSE) samples [PDF]

Environmental Health and Toxicology, 2018
Cigarette smoke is a major risk factor for several diseases, including chronic obstructive pulmonary and cardiovascular diseases. The toxicity of the cigarette smoke can be determined in vitro.
Yong-Hyun Kim, Young-Ji An, Seongwon Jo, Sang-Hyub Lee, Sang Jin Lee, Seong-Jin Choi, Kyuhong Lee   +6 more
doaj   +1 more source