Results 91 to 100 of about 519,356 (304)

Risks inherent in fetal gene therapy [PDF]

Nature, 1999
D, King, T, Shakespeare, R, Nicholson, A, Clarke, S, McLean   +4 more
openaire   +3 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Inherent Safety Intervention Framework [PDF]

, 2008
Despite being an attractive proposition in terms of safety and cost performance, the actual implementation of Inherent Safety in design is not widely observed in the industries.
Chan , Tuck Leong
core  

Research on reliability index and failure probability of inherent defect insurance from the insurance perspective

Heliyon
With the continuous improvement of people ‘s living standards, people have put forward higher requirements for the safety and comfort of housing. Therefore, Inherent Defect Insurance, a financial method to guarantee the quality of construction projects ...
Zeyu Chen, Xikang Yan, Lida Wang, Qinyu Luo, Yunhan Yan, Tian Qiu, Peng Cheng   +6 more
doaj   +1 more source

Mammographic density and risk of breast cancer by tumor characteristics: a case-control study

BMC Cancer, 2017
Background In a previous paper, we had assumed that the risk of screen-detected breast cancer mostly reflects inherent risk, and the risk of whether a breast cancer is interval versus screen-detected mostly reflects risk of masking.
Kavitha Krishnan, Laura Baglietto, Jennifer Stone, Catriona McLean, Melissa C. Southey, Dallas R. English, Graham G. Giles, John L. Hopper   +7 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Food plant toxicants and safety - Risk assessment and regulation of inherent toxicants in plant foods [PDF]

, 1998
The ADI as a tool for risk management and regulation of food additives and pesticide residues is not readily applicable to inherent food plant toxicants: The margin between actual intake and potentially toxic levels is often small; application of the ...
Herman, J., Essers, A.J., Gry, J., Ciere, S., Bouwmeister, P., Mortby, E., Sandra Ciere, Herrman, J., Bouwmeister, P.J., John Herrman, Luciano Vittozzi, Shrimpton, D.H., Andrew G Renwick, Speijers, G.J.A., Renwickn, A.G., Koeman, J.H., Jørn Gry, Piet A van den Brandt, Gerrit M Alink, Alink, G.M., Vittozzi, L., A.J.Alexander Essers, Gerrit J.A Speijers, van den Brandt, P.A., Pieter-Jan Bouwmeister, Alexander, J., Derek H Shrimpton, Renwick, A.G., Vainio, H., Harri Vainio, Kuiper, H.A., Harry A Kuiper, Eileen Mortby, Jan Alexander, Jan H Koeman, Gry, Jørn, Essers, A.J.A., Brandt, P.A., van den   +37 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Information and Attitudes to Risk at the Track [PDF]

There have been many attempts, theoretical and empirical, to explain the persistence of a favorite-longshot bias in various horse betting markets.
Sara Westreich, Adi Schnytzer
core  

Perceived Risk As A Factor In Store Choice: An Examination Of Inherent Versus Handled Risk

, 1990
Perceived risk as an influence on consumer behavior has been well documented.  Despite the popularity of the topic, only a few studies have examined the risks consumers perceive when selecting a retail patronage mode.  The study uses Bettman’s concept of
Dunn, Mark G., Lumpkin, James R.
core   +1 more source