Results 141 to 150 of about 1,685,014 (305)

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Risk Management in the Exchange Fund Account [PDF]

open access: yes
In this article, author Michel Rochette of the Bank's Risk-Management Unit briefly describes the initiatives undertaken to identify, analyze, model, and manage the principal risks inherent in the transactions of the Exchange Fund Account (EFA), where the
Michel Rochette
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Catastrophe Risks Inherent in Japanese Life Insurance

open access: yesHokengakuzasshi (JOURNAL of INSURANCE SCIENCE), 2007
日本は,少子高齢化が続く過程で,東京一極集中を強化しつつあり,地震・核テロ・鳥インフルエンザ等のリスクは,RMS社の調査等によれば,予想外に高まっているように思われる。日本の生保業界においては,核テロ等の可能性を考えた場合,昼間にビル単位でどれだけの付保がされているかを試算しておく必要もあろう。東京都の昼間人口調査(2000年)では,皇居も含めた千代田区の昼間人口密度は7万3千人/km2となっており,皇居を除いた人口密度は一層高く,丸の内再開発で,極度の集中化が一層進みつつある。これへの対応策としては,(1) ビル単位で,再保険への出再を検討する。(2) 約款の保険金支払免責条項に,テロ・地震を戦争その他の変乱と同様に,保険金削減の対象である旨,明記する。などが考えられるが ...
openaire   +2 more sources

Why should we believe the market this time? ECMI Commentary No. 22, 23 February 2009 [PDF]

open access: yes, 2009
During the decade preceding the eruption of the financial crisis in August 2007, rating agencies and market participants, gripped by euphoria, systematically underestimated the risk inherent in a wide range of financial assets.
De Grauwe, Paul.
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Inherent Risk Factors for Nosocomial Infection in the Long Stay Critically Ill Child Without Known Baseline Immunocompromise: A Post Hoc Analysis of the CRISIS Trial. [PDF]

open access: yesPediatr Infect Dis J, 2016
Carcillo JA   +20 more
europepmc   +1 more source

Government policy and the financial sector : dealing with moral hazard and "too-big-to-fail" [PDF]

open access: yes, 2009
The large-scale interventions by Western governments in 2008 aimed at underpinning the banking system have confirmed the extent of state support for the financial sector.
Choudhry, Moorad, Landuyt, Gino
core  

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