Results 191 to 200 of about 82,434 (287)

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

Advanced Science, EarlyView.
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra, Jadon Compher, Akhil Prabhavalkar, Mireya Almaraz, Claudia Cedeño Kwong, Christine Baal, Maria Talantova, Nima Dolatabadi, Julian Piña‐Sanz, Yubo Wang, Leonard Yoon, Swagata Ghatak, Zi Gao, Yuting Zhang, Dorit Trudler, Lynee Massey, Wei Lin, Anthony Balistreri, Michael Bula, Nicholas J. Schork, Tony S. Mondala, Steven R. Head, Jeffery W. Kelly, Stuart A. Lipton   +23 more
wiley   +1 more source

Inheritance patterns, challenges, and outcomes of fracture management in osteopetrosis patients. CASE series and review of pertinent literature. [PDF]

Ann Med Surg (Lond), 2018
Hasan O, Pathan AZ, Naqi H, Aqueel T, Hashmi P, Lakdawala RH.   +5 more
europepmc   +1 more source

Mapping the Non‐Canonical Splicing Variants: Decrypting the Hidden Genetic Architecture of Idiopathic Male Infertility

Advanced Science, EarlyView.
This study highlights the significance of non‐canonical splicing variants in male infertility, a factor often overlooked during the analysis of high‐throughput sequencing data. Incorporating the non‐canonical splicing variants prioritization in the genetic analysis pipeline will increase the genetic diagnosis of patients with male infertility ...
Kuokuo Li, Yuge Chen, Dongdong Tang, Yuying Sheng, Xu Han, Hao Geng, Na Zhang, Zongliu Duan, Guanxiong Wang, Yang Gao, Rui Guo, Rong Hua, Zhiming Ding, Chuan Xu, Qunshan Shen, Zhen Yu, Bing Song, Mingrong Lv, Yuping Xu, Huan Wu, Ji Wu, Yunxia Cao, Xiaojin He   +22 more
wiley   +1 more source

Inheritance patterns in metabolism and growth in diallel crosses of Arabidopsis thaliana from a single growth habitat. [PDF]

Heredity (Edinb), 2018
Rodriguez Cubillos AE, Tong H, Alseekh S, de Abreu E Lima F, Yu J, Fernie AR, Nikoloski Z, Laitinen RAE.   +7 more
europepmc   +1 more source

A Novel 10‐Protein Score for Liver Fat Content Predicts Cardiovascular‐Kidney‐Metabolic Disease Risk

Advanced Science, EarlyView.
A novel 10‐protein plasma score precisely quantifies liver fat, outperforming the fatty liver index. It robustly predicts the risk of numerous cardiovascular‐kidney‐metabolic diseases and integrates with genetic data for precision prevention, offering a practical alternative to magnetic resonance imaging (MRI). Abstract Liver fat content (LFC) is a key
Xiaoqin Gan, Yuanxiu Wei, Yiting Wu, Xinyue Su, Gangling Wang, Sisi Yang, Ziliang Ye, Yanjun Zhang, Hao Xiang, Yu Huang, Yiwei Zhang, Yuanyuan Zhang, Xianhui Qin   +12 more
wiley   +1 more source

Inheritance patterns of plumage coloration in common buzzards Buteo buteo do not support a one-locus two-allele model. [PDF]

Biol Lett, 2018
Kappers EF, de Vries C, Alberda A, Forstmeier W, Both C, Kempenaers B.   +5 more
europepmc   +1 more source

Mutation of a Single CTCF Target Site within the H19 Imprinting Control Region Leads to Loss of Igf2 Imprinting and Complex Patterns of De Novo Methylation upon Maternal Inheritance

, 2004
Vinod Pant, Sreenivasulu Kurukuti, Elena M. Pugacheva, Shaharum Shamsuddin, Piero Mariano, Rainer Renkawitz, Elena Klenova, Victor V. Lobanenkov, Rolf Ohlsson   +8 more
openalex   +1 more source

Subclonal architecture, evolutionary trajectories and patterns of inheritance of germline variants in pediatric glioblastoma [PDF]

, 2018
Mary Hoffman, Aaron H. Gillmor, Daniel J. Kunz, Michael J. Johnston, Ana Nikolić, Kiran Narta, Jennifer C. King, Katrina Ellestad, Ngoc Ha Dang, Florence M.G. Cavalli, Michelle Kushida, Fiona J. Coutinho, Betty Luu, Yussanne Ma, Andrew J. Mungall, Richard A. Moore, Marco A. Marra, Michael D. Taylor, Trevor J. Pugh, Peter B. Dirks, Donna L. Senger, Benjamin D. Simons, Jennifer A. Chan, A. Sorana Morrissy, Marco Gallo   +24 more
openalex   +1 more source

Niδ+ Atoms Anchored In Situ on Ultrathin Ni‐Phyllosilicate Nanosheet Ensure High‐Efficient CO2 Reduction into CO at Moderate‐Low Temperature

Advanced Science, EarlyView.
A novel supported Ni‐based catalyst, consisting of abundant Niδ+ atoms with low electron density anchored in situ on ultrathin Ni‐phyllosilicate nanosheet (a‐Niδ+−PSNS, 0< δ ≤1), achieve simultaneous outstanding CO2 conversion and CO selectivity. Their ultrathin nanosheet enables abundant anchored Niδ+ atoms to fully expose and disperse, which can ...
Ziluo Ding, Pengfei Li, Qiang Chang, Dongdong Xiao, Xingchen Liu, Wentao Zheng, Hao Yang, Shan He, Fan Wang, Jianguo Wang, Fei Wang   +10 more
wiley   +1 more source

Modern and Ancient Genomes Reveal Neolithic Paternal Expansions of Millet and Rice Farmers and Demic Diffusion from China into Mainland Southeast Asia

Advanced Science, EarlyView.
This study clarifies the genetic patterns of paternal lineages across East Asia and Mainland Southeast Asia. Han populations are relatively homogeneous, whereas southern ethnolinguistic minorities display regional structures. Shared Y‐chromosome lineages indicate Neolithic expansions and extensive north‐south gene flow, supporting demic diffusion ...
Yunhui Liu, Lintao Luo, Yutong Jiang, Minzhu Zhao, Ting Yang, Zhiyong Wang, Lisiteng Luo, Yuhang Feng, Zihao Zhu, Yuzhu Wang, Limei Zhang, Bofeng Zhu, Chao Liu, Renkuan Tang, Mengge Wang, Guanglin He   +15 more
wiley   +1 more source