Results 71 to 80 of about 7,416 (133)

Development of White Cabbage, Coffee, and Red Onion Extracts as Natural Phosphodiesterase-4B (PDE4B) Inhibitors for Cognitive Dysfunction: In Vitro and In Silico Studies

Advances in Pharmacological and Pharmaceutical Sciences
Human cognition fundamentally depends on memory. Alzheimer’s disease exhibits a strong correlation with a decline in this factor. Phosphodiesterase-4 B (PDE4B) plays a crucial role in neurodegenerative disorders, and its inhibition is one of the promising approaches for memory enhancement.
Nazir Ahmad, Kaisun Nesa Lesa, Navista Sri Octa Ujiantari, Bambang Sudarmanto, Nanang Fakhrudin, Zullies Ikawati   +5 more
openaire   +3 more sources

Hipertensión pulmonar y enfermedad del tejido conectivo, una grave presentación

Revista Médica Clínica Las Condes
Resumen: Introducción: La hipertensión arterial pulmonar (HAP) es una condición rara con presión arterial pulmonar elevada (>20 mmHg) y resistencia vascular aumentada. Afecta entre 5 y 15 adultos por millón, y provoca disnea, dolor torácico, y riesgo de
Neguith Marrugo, MD, Elián Giordanino, MD, Gerardo Palma, MD, Juan Carlos Venegas, MD   +3 more
doaj  

Dermatologists' Role in the Early Diagnosis of Psoriatic Arthritis: Expert Recommendations. [PDF]

Actas Dermosifiliogr (Engl Ed), 2020
Belinchón I, Salgado-Boquete L, López-Ferrer A, Ferran M, Coto-Segura P, Rivera R, Vidal D, Rodríguez L, de la Cueva P, Queiro R.   +9 more
europepmc   +1 more source

Phosphodiesterase-7-inhibiting heterocyclic derivatives

, 2011
[EN] The present invention provides a novel series of compounds of general formula (I) and (II) belonging to a wide family of heterocyclic derivatives that exhibit activity for treating diseases in which PDE7 inhibition is therapeutic, preferably for inflammatory, autoimmune and neurodegenerative diseases.
Gil, Carmen, Martínez Gil, Ana, Redondo, Miriam, Campillo, Nuria E., Pérez, Daniel I., Loza García, María Isabel, Cadavid Torres, María Isabel, Brea Floriani, José, Pérez Castillo, Ana   +8 more
openaire   +1 more source

[Diagnosis and Treatment of Pulmonary Embolism and Pulmonary Hypertension in Patients With Interstitial Lung Disease]. [PDF]

Open Respir Arch
León-Román F, Pintado-Cort B, Barberà JA, Sellares J, Iturbe D, López-Zubizarreta M, Peña-Miguel T, Durán-Barata D, Jiménez D.   +8 more
europepmc   +1 more source

Efectos del tratamiento crónico con inhibidores de fosfodiesterasas (PDEe y PDE7) de ratones EAE en la actividad de señalización de la PKA

, 2013
Peer ...
openaire   +1 more source

[New perspectives in the pharmacological treatment of COPD]. [PDF]

Aten Primaria
Simonet PJ.
europepmc   +1 more source

[Chronic obstructive pulmonary disease in real life. LEONPOC study]. [PDF]

Aten Primaria, 2017
García García S, Carazo Fernández L, Juan García J, Naveiro Rilo JC.   +3 more
europepmc   +1 more source

Estudio comparativo entre inhibidores selectivos de la fosfodiesterasa 4B, Roflumilast N-óxido y corticosteroides en modelos in vitro de Enfermedad Pulmonar Obstructiva Crónica: papel potencial en interacción leucocito/endotelio

, 2016
[EN] Chronic Obstructive Pulmonary Disease (COPD) is characterized by a progressive limitation of the airflow that is not fully reversible. In North America, between three and seven million people are diagnosed with COPD each year, and this disease is presently the fourth leading cause of death in developed countries.
openaire   +1 more source