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Inhibins: from reproductive hormones to tumor suppressors
Trends in Endocrinology and Metabolism, 2010Kaye L Stenvers, Jock K Findlay
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Physiological Reviews, 1988
Inhibin has been defined as a gonadal hormone that exerts a specific negative feedback action on the secretion of FSH from the gonadotropic cells of the pituitary gland. The existence of inhibin was postulated as early as 1923 (250). However, only after reliable and sensitive bioassay systems for the detection and estimation of inhibin had been ...
A S, McNeilly, C G, Tsonis, D T, Baird
+7 more sources
Inhibin has been defined as a gonadal hormone that exerts a specific negative feedback action on the secretion of FSH from the gonadotropic cells of the pituitary gland. The existence of inhibin was postulated as early as 1923 (250). However, only after reliable and sensitive bioassay systems for the detection and estimation of inhibin had been ...
A S, McNeilly, C G, Tsonis, D T, Baird
+7 more sources
Structure of two human ovarian inhibins
Biochemical and Biophysical Research Communications, 1986P H Seeburg, H D Niall, Peter H Seeburg
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Roles of Inhibins, Activins, and Follistatin in the Female Reproductive System
Frontiers in Neuroendocrinology, 1996P G Knight
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Inhibins in Normal Male Physiology
Seminars in Reproductive Medicine, 2004Anne O'Connor, David M De Kretser
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Journal of Andrology, 1996
Structure of Inhibin and Related Proteins Two forms of inhibin were isolated from ovarian follicular fluid. They are termed inhibin A and inhibin B to denote two differing glycoprotein hormones, which share a common subunit (a) and dissimilar subunits, respectively called 13A and 13B’ which formed disulfide-linked dimeric proteins with the capacity to ...
D M, De Kretser, J R, McFarlane
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Structure of Inhibin and Related Proteins Two forms of inhibin were isolated from ovarian follicular fluid. They are termed inhibin A and inhibin B to denote two differing glycoprotein hormones, which share a common subunit (a) and dissimilar subunits, respectively called 13A and 13B’ which formed disulfide-linked dimeric proteins with the capacity to ...
D M, De Kretser, J R, McFarlane
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Archives of Andrology, 1980
The bioassays developed so far, although good for detecting inhibin from different sources and for monitoring their purification, are not really practical for physiological studies. Moreover, they are influenced by steroidal hormones. In this regard radioimmunoassays, with their high capacity and greater sensitivity, are of immense value in studies ...
S B, Moodbidri, A Y, Vaze, A R, Sheth
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The bioassays developed so far, although good for detecting inhibin from different sources and for monitoring their purification, are not really practical for physiological studies. Moreover, they are influenced by steroidal hormones. In this regard radioimmunoassays, with their high capacity and greater sensitivity, are of immense value in studies ...
S B, Moodbidri, A Y, Vaze, A R, Sheth
openaire +2 more sources
Journal of Reproductive Immunology, 1998
Previous observations from our laboratory have demonstrated that the levels of immunoreactive inhibin (ir-inh) are elevated in almost all patients with granulosa cell tumors and in the majority of postmenopausal women with mucinous ovarian cancers.
H G, Burger +13 more
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Previous observations from our laboratory have demonstrated that the levels of immunoreactive inhibin (ir-inh) are elevated in almost all patients with granulosa cell tumors and in the majority of postmenopausal women with mucinous ovarian cancers.
H G, Burger +13 more
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Inhibin and Inhibin-Related Proteins
1993Abstract It has been recognized for many years that the gonads produce a nonsteroidal factor termed inhibin that preferentially suppresses pituitary follicle-stimulating hormone (FSH) secretion. Progress in its isolation, characterization, and clarification of its physiology, however, has only occurred since 1985 after the development
David M Robertson +2 more
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1988
Publisher Summary This chapter discusses the isolation, structure, characterization, and biosynthesis of inhibins and activins. The two pituitary gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) which regulate the development and maturation of the gonad, are identified.
N, Ling +7 more
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Publisher Summary This chapter discusses the isolation, structure, characterization, and biosynthesis of inhibins and activins. The two pituitary gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) which regulate the development and maturation of the gonad, are identified.
N, Ling +7 more
openaire +2 more sources