Results 271 to 280 of about 4,357,163 (359)

Mechanisms of Calcineurin Inhibitor-Induced Neurotoxicity: A Systematic Literature Review

Pokorny, Laszlo
openalex   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Developmental regulation of Erk signaling by mitotic kinases. [PDF]

Sci Adv
Chen F, Bruder JM, Govindasamy N, Wu J, Chen R, Prit D, Drexler HCA, Leidel SA, Schöler HR, Bedzhov I.   +9 more
europepmc   +1 more source

Discovery andOptimizationof Novel Tricyclic Ubiquitin-SpecificProtease 1 Inhibitors for the Treatment of BRCA-Mutated Breast Cancer

Tianning Xiong (16639670), Hong Yang (37298), Songwen Lin (1622227), Li Sheng (118074), Junpu Ge (21548152), Jinhua Wang (1506), Heng Xu (244639)   +6 more
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Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Combination therapy with mineralocorticoid receptor antagonists and SGLT2 inhibitors versus SGLT2 inhibitor monotherapy in chronic kidney disease: an updated meta-analysis of randomized controlled trials. [PDF]

BMC Nephrol
Muhammad Daniyal S, Ajaz H, Riaz M, Murad Khatoon N, Aftab Z, Tauqir Gondal H, Gul I, Sarwar M, Batool F, Fahim SL, Noor A, Khalid A, Ashraf DA, Jabarkhil R.   +13 more
europepmc   +1 more source

Table 1_Comparison of tegoprazan-based and proton pump inhibitor-based regimens for Helicobacter pylori eradication: a meta-analysis and systematic review.docx

Xin Zhang (35492), Xing Li (134367), Jiangguo Li (21565820), Yuexia Deng (17780919), Wei Xu (28953), Dongkui Chen (15424475), Licheng Wei (7066121)   +6 more
openalex   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Transcriptional Profiling Reveals Lineage-Specific Characteristics in ATR/CHK1 Inhibitor-Resistant Endometrial Cancer. [PDF]

Biomolecules
Huang TT, Lee JM.
europepmc   +1 more source

Discovery ofa Novel and Potent MET Transcription Inhibitor TargetingPromoter G‑Quadruplex forthe Treatment of NSCLC

Wenjian Min (11560191), Chunling Chen (79232), Zhongrui Shi (21085149), Huanaoyu Yang (14093611), Yanyin Wang (13047953), Junfeng He (4252039), Qiman Zhang (19830156), Yunchu Zhao (21466631), Yi Hou (148620), Jiayu Ding (12005975), Yasheng Zhu (8049617), Chengliang Sun (715954), Kai Yuan (289810), Peng Yang (296696), Xiao Wang (19312)   +14 more
openalex   +1 more source