Results 51 to 60 of about 11,646 (331)
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Spartan Daily, September 23, 2004 [PDF]
, 2004 Volume 123, Issue 18https://scholarworks.sjsu.edu/spartandaily/10022/thumbnail ...
San Jose State University, School of Journalism and Mass Communications
core +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
An early Anglo-Saxon cemetery at Quarrington, near Sleaford, Lincolnshire : report on excavations, 2000-2001 [PDF]
, 2004 [FIRST PARAGRAPH] The early Anglo-Saxon cemeteries in the Kesteven part of Lincolnshire form two distinct distribution patterns (Fig.1): a north-south line along, or just to the west of, the limestone edge between the former Roman towns of Lincoln and ...
Dickinson, T.M.
core
Five or six step scenario for evolution?
, 2007 The prediction that (due to the limited amount of hydrogen available as fuel in the Sun) the future duration of our favourable terrestrial environment will be short (compared with the present age of the Earth) has been interpreted as evidence for a hard ...
Barrow, Brandon Carter, Gore, Schopf
core +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Tomb number 2 of the Church of St. Michael in Mornago (Varese, Italy). Anthropological and archaeological study of medieval funeral remains [PDF]
, 2017 The current paper aims to present the archaeological and anthropological results of the investigation conducted on a medieval burial which presents several features that recall the Longobard culture.
Badino, Paola +2 more
core
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source