Results 61 to 70 of about 103,104 (262)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Comparison of the effect of preload and curvature of composite laminate under impact loading [PDF]
FME Transactions, 2016 In this paper, the effect of preload on impact response of composite laminates is considered. To this aim, three specimens were manufactured and tested under 4 different impact conditions: 1- A curved laminate without preload.
Saghafi H. +4 more
doaj
Scoliosis: current overview and treatment considerations
Brazilian Neurosurgery, 2010 Scoliosis presents with lateral curvature of the spine greater than 10 degrees in x-ray and it can be associated with others deformities of the curvature of the spine.
Elton Gomes da Silva +3 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Curvature and topology dependency of the cosmological spectra
Results in Physics, 2019 In this article we investigate dependency of two important cosmological random fields defined on spatial slices of the FLRW universe and their spectra on the geometry and topology of the background universe.
Ali A. Asgari +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Idealized Initial Conditions and Solution for Curvature Perturbations
Abstract Combining Einstein equations and a scalar field evolution equation, obtained in Chap. 3 , we derive a Mukhanov-Sasaki equation for a gauge-invariant curvature perturbation, defined in Chap. 4 . Proceeding to its solution, we
Mikko Laine, Simona Procacci
openaire +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Effect of Random Distribution of Initial Imperfection Curvature on The Bearing Capacity of Double -Layer Flat Grids With Different Configurations [PDF]
مدلسازی پیشرفته در مهندسی عمرانSpace frame structures have recently received significant attention for covering large spaces due to their high degree of indeterminacy, considerable stiffness, and low weight.
Arash Bayat, Hamidreza Ashrafi
doaj +1 more source