Results 131 to 140 of about 2,782,327 (303)
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
Polynomial Initial-State Jumps and Christoffel Transforms in Krylov Complexity
State Krylov, or spread, complexity belongs to the cyclic pair $(H,|K_0\rangle)$, so changing the initial state at fixed-$H$ reorganizes the Lanczos chain within the reference cyclic subspace. For normalized polynomial descendants $|ψ_Q\rangle \propto Q(H)|K_0\rangle$, this reorganization is the positive Christoffel reweighting of the reference measure
Chowdhury, Abhishek +1 more
openaire +2 more sources
Limit Theorems for Reinforced Jump Processes on Regular Trees [PDF]
Consider a vertex-reinforced jump process defined on a regular tree, where each vertex has exactly b children, with b >= 3. We prove the strong law of large numbers and the central limit theorem for the distance of the process from the root.
Andrea Collevecchio
core
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
First-return time in fractional kinetics
Modern Stochastics: Theory and ApplicationsThe first-return time is the time that it takes a random walker to go back to the initial position for the first time. In this paper, the first-return time is studied when random walkers perform fractional kinetics, specifically fractional diffusion ...
Marcus Dahlenburg, Gianni Pagnini
doaj +1 more source
Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma
Molecular Oncology, EarlyView.Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara +10 more
wiley +1 more source
Jump Start or False Start? A Theoretical and Empirical Evaluation of LLM-initialized Bandits
CoRRThe recent advancement of Large Language Models (LLMs) offers new opportunities to generate user preference data to warm-start bandits. Recent studies on contextual bandits with LLM initialization (CBLI) have shown that these synthetic priors can significantly lower early regret.
Adam Bayley +4 more
openaire +3 more sources
Robust estimation of intraweek periodicity in volatility and jump detection. [PDF]
Opening, lunch and closing of financial markets induce a periodic component in the volatility of high-frequency returns. We propose a non-parametric weighted standard deviation and parametric truncated maximum likelihood estimation procedure for the ...
Croux, Christophe +2 more
core
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
BiomechanicsBackground/Objectives: In Rhythmic Gymnastics (RG), the jump is an element of great difficulty that requires the qualities of strength and coordination.
Manuel Nogueras +2 more
doaj +1 more source