Movement Disorders in Aicardi–Goutières Syndrome and Response to Immunomodulation
ABSTRACT This study characterizes movement disorders and treatment responses in seven children with Aicardi–Goutières syndrome (AGS). We retrospectively evaluated motor phenotypes, neuroimaging, and interferon signatures in patients treated with baricitinib or anifrolumab. Spasticity affected all patients, while dystonia was present in 4/7.
Enrique Gonzalez Saez‐Diez +10 more
wiley +1 more source
ABSTRACT Just recently, successful chimeric antigen receptor (CAR) T cell therapy was reported in the first patient with refractory, anti‐diacylglycerol lipase alpha (DAGLA) antibody‐mediated autoimmune encephalitis, achieving partial clinical remission.
Dimitrios Mougiakakos +9 more
wiley +1 more source
Comparation of vertical jump and rebound with basketball athletes on initiation
Este estudo tem como tema a comparação entre impulsão vertical e rebote de alunos de uma Escola de Esporte de Taubaté para verificar se hárelação entre quem salta mais alto e quem consegue pegar mais rebotes. Por meio de uma pesquisa qualitativa com indivíduos com idade de 12 a 16 anos, de ambos os sexos, o objetivo deste estudo é de utilizar ...
openaire +1 more source
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou +16 more
wiley +1 more source
Long‐Term Efficacy of Immunotherapy in Autoimmune Autonomic Ganglionopathy—A 10‐Year Follow Up Study
ABSTRACT Objective Autoimmune autonomic ganglionopathy (AAG) is a rare but potentially treatable cause of severe autonomic failure. Evidence guiding long‐term immunotherapy, treatment sequencing, and residual autonomic impairment is limited. We evaluated long‐term treatment response, residual autonomic dysfunction, and relapse patterns in patients with
Giacomo Chiaro +6 more
wiley +1 more source
Jump assessment on a force plate-an approach to quantify subtle lower limb neuromuscular deficits in people with multiple sclerosis. [PDF]
Geßner A +4 more
europepmc +1 more source
T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ±
Sarah J. Wright +10 more
wiley +1 more source
Kinematic determinants of take-off performance in elite and sub-elite male long jumpers: a competition-based two-dimensional motion analysis. [PDF]
Wei P, Yuan T, Xie Z.
europepmc +1 more source
Value Function Initialization for Knowledge Transfer and Jump-start in Deep Reinforcement Learning
Value function initialization (VFI) is an effective way to achieve a jumpstart in reinforcement learning (RL) by leveraging value estimates from prior tasks. While this approach is well established in tabular settings, extending it to deep reinforcement learning (DRL) poses challenges due to the continuous nature of the state-action space, the noisy ...
openaire +2 more sources
Retractions in Rheumatology: Trends, Causes, and Implications for Research Integrity
Objective We aimed to describe the trends and main reasons for study retraction in rheumatology literature. Methods We reviewed the Retraction Watch database to identify retracted articles in rheumatology. We recorded the main study characteristics, authors’ countries, reasons for retraction, time from publication to retraction, and trends over time ...
Anna Maria Vettori, Michele Iudici
wiley +1 more source

