Results 51 to 60 of about 7,682,939 (300)

Delay in seeking medical help following Transient Ischemic Attack (TIA) or "mini-stroke": a qualitative study. [PDF]

PLoS ONE, 2014
Prompt treatment following Transient Ischemic Attack (TIA) can reduce the risk of subsequent stroke and disability. However, many patients delay in making contact with medical services.
Jennifer Mc Sharry, Alison Baxter, Louise M Wallace, Anthony Kenton, Andrew Turner, David P French   +5 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Correlates of Delayed Initial Contact to Emergency Services among Patients with Suspected ST-Elevation Myocardial Infarction

Cardiology Research and Practice, 2021
Background. Early diagnosis and treatment of a patient displaying symptoms of myocardial ischemia is paramount in preventing detrimental tissue damage, arrhythmias, and death.
Osayi Lawani, Nicholas Gorman, Fiona Gorman, Jiries Ganim, Stefano Sdringola-Maranga   +4 more
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Indicators for ecosystem services and vulnerabilities in the Mediterranean Sea. An initial application

Ecological Indicators
Economy and society rely on a healthy marine ecosystem to meet a number of tangible and intangible needs. However, understanding the composition and trends in the exchange between the marine ecosystem and the socio-economic system is key to inform ...
Alessandra La Notte, Anna Maria Addamo, Silvia Ferrini, Gaetano Grilli, Luca Polimene, Diego Macias   +5 more
doaj   +1 more source

Are one-stop centres an appropriate model to deliver services to sexually abused children in urban Malawi?

BMC Pediatrics, 2018
Background The Republic of Malawi is creating a country-wide system of 28 One-Stop Centres (known as ‘Chikwanekwanes’ - ‘everything under one roof’) to provide medical, legal and psychosocial services for survivors of child maltreatment and adult ...
Yabwile Mulambia, Aaron J. Miller, Geraldine MacDonald, Neil Kennedy   +3 more
doaj   +1 more source

Composition of Resource-Service Chain Based on Evolutionary Algorithm in Distributed Cloud Manufacturing Systems

IEEE Access, 2020
In distributed cloud manufacturing (CMfg) systems, multi-resource service can complete more complex manufacturing tasks than single resource service. Especially in business process, all the resource services are invoked in a certain sequence, which is ...
Haibo Li, Shaoyuan Weng, Juncheng Tong, Ting He, Wenyun Chen, Mengmeng Sun, Yingtong Shen   +6 more
doaj   +1 more source

Initiating Development Of Genetic Counseling Services In The Health Services Unit: An Initial Assessment

, 2010
Medical industry has grown rapidly take advantage of the knowledge, resources, and various applications of genetic techniques to solve various problems related to the benefit of mankind. As a result of developments in this realm of genetic, genomic medicine appears focused on the health sector.
Rujito, Lantip, Ghozali, Paulus
openaire   +2 more sources