Results 41 to 50 of about 2,566,738 (350)
FEBS Letters, EarlyView.Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
wiley +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Smoothness of solutions of conjugate boundary-value problems on a measure chain
Electronic Journal of Differential Equations, 2000 In this paper we consider the n-th order $Delta$-differential equation (often refered to as a differential equation on a measure chain) $$u^{Delta_n}(t) = f(t, u(sigma(t)),dots, u^{Delta_{n-1}}(sigma(t)))$$ satisfying n-point conjugate boundary ...
Eric R. Kaufmann
doaj
Singularity Excitations and Initial Value Problem in Continuous LTI Systems
IEEE Access, 2020 A modern challenge in electrical engineering education is to keep the math at a sufficient level, with a goal to find an optimal balance between calculus competence and operative skills needed for real-life technical applications. It is not uncommon that
Milan M. Ponjavic, Tomislav B. Sekara
doaj +1 more source
THE INITIAL VALUE PROBLEM IN NUMERICAL RELATIVITY [PDF]
Journal of Hyperbolic Differential Equations, 2005 The conformal method for constructing initial data for Einstein's equations is presented in both the Hamiltonian and Lagrangian picture (extrinsic curvature decomposition and conformal thin sandwich formalism, respectively), and advantages due to the recent introduction of a weight-function in the extrinsic curvature decomposition are discussed.
openaire +3 more sources
FEBS Open Bio, EarlyView.This study presents a novel approach to teaching Python and bioinformatics using team‐based learning and cloud‐hosted notebooks. By integrating interactive coding into biomedical education, the method improves accessibility, student engagement, and confidence—especially for those without a computing background.
Nuno S. Osório, Leonardo D. Garma
wiley +1 more source
Countable hyperbolic systems in the theory of nonlinear oscillations
Karpatsʹkì Matematičnì Publìkacìï, 2016 In this article a model example of a mixed problem for a fourth-order differential equation reduced to initial-boundary value problem for countable hyperbolic system of first order coherent differential equations.
T.I. Firman
doaj +1 more source
Numerical relativity approach to the initial value problem in asymptotically anti–de Sitter spacetime for plasma thermalization: An ADM formulation [PDF]
, 2012 This article studies a numerical relativity approach to the initial value problem in Anti-de Sitter spacetime relevant for dual non-equilibrium evolution of strongly coupled non-Abelian plasma undergoing Bjorken expansion.
M. Heller, R. Janik, P. Witaszczyk
semanticscholar +1 more source
NMDAR‐Antibody Encephalitis Diagnosed With Primary Central Nervous System Lymphoma: A Case Series
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT N‐methyl‐D‐aspartate receptor‐antibody encephalitis (NMDAR encephalitis) is one of the most common forms of autoimmune encephalitis, with a paraneoplastic relationship described in approximately 38%. Primary central nervous system lymphoma (PCNSL) is a rare hematologic malignancy that is not often considered as the underlying neoplasm in this ...
Soo Hyun Ahn +4 more
wiley +1 more source