Results 141 to 150 of about 1,507,854 (249)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Early Versus Later Anticoagulation After Ischemic Stroke in Atrial Fibrillation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. [PDF]

Hosp Pharm
Kow CS, Ramachandram DS, Thiruchelvam K, Hasan SS, Zaihan AF.   +4 more
europepmc   +1 more source

Inhibition of the initiation of leukemic transcription by N-trifluoroacetyladriamycin-14-O-hemiadipate in vitro. Impaired formation of RNA polymerase-DNA complex.

, 1984
L.F. Chuang, Mervyn Israel, Ronald Y. Chuang   +2 more
openalex   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Relapse activity after assisted reproductive technology treatments in women with multiple sclerosis: a nationwide cohort study in Denmark. [PDF]

J Neurol Neurosurg Psychiatry
von Kappelgaard L, Framke E, Vassard D, Pinborg A, Schwarze JE, Sabidó M, Magyari M.   +6 more
europepmc   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Exploring Breastfeeding and Exclusive Breastfeeding Practices Among Saudi Women: Knowledge, Attitudes, and the Role of Counseling. [PDF]

Sage Open Pediatr
Alkhaifi S, Bashawyah S, Alsulami A, Hashroof Z, Aljoudi S.   +4 more
europepmc   +1 more source

An Aspect of the Fatigue Carck Initiation in Butt Welded Joint

, 1968
Jyunjiro Muraki, Takayoshi Ishiguro, Mitsugu Hanzawa, Hikojiro Yokota   +3 more
openalex   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Targeting Molecular Collagen Defects from the Initiation of Knee Osteoarthritis [PDF]

Kui Huang, Rongmao Qiu, Yijie Fang, Dantian Zhu, Xiaojing Li, Zhongyang Lv, Taoyu Jia, Yuxiang Fei, Daoning Zhou, Wenjun Wu, Yongjie Huang, Suwen Zhao, Yongqiao Zhu, Shaolin Li, Dongquan Shi, Yang Li   +15 more
openalex   +1 more source