Results 201 to 210 of about 1,507,854 (249)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Beyond the Surface: Novel Therapy Approach for Pancreatitis in the Setting of CFTR Dysfunction. [PDF]

Case Rep Gastrointest Med
Wright BA, Hodapp E, Hornick DB, Peña TA.   +3 more
europepmc   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Decentralising drug-resistant TB treatment initiation services. [PDF]

IJTLD Open
Murphy-Okpala N, Eze C, Orabueze IN, Ezenwosu I, Nwafor C, Ekeke N, Ezeakile O, Chukwu JN, Matiku S, Meka A, Njoku M, Kirubi B, Iyama F, Ossai E, Chijioke-Akaniro O, Creswell J.   +15 more
europepmc   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Trends in initiation of regular cigarette smoking in 28 European countries, 1940-2019: retrospective reconstruction from repeated cross-sectional surveys. [PDF]

Eur J Public Health
Teshima A, Bannon O, Filippidis FT, Feliu A, Gallus S, Peruga A, Martínez C, Fernández E.   +7 more
europepmc   +1 more source

Acoustic emission from the initiation of plastic deformation of Polyethylenes during tensile tests

, 2014
Nicolas Casiez, Stéphanie Deschanel, Thomas Monnier, Olivier Lame   +3 more
openalex   +2 more sources

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Influence of Intraocular Pressure on Clinical Decision-Making in Glaucoma Management.

JAMA Ophthalmol
Polski A, Brintz BJ, Hess R, Kawamoto K, Medeiros FA, Stein JD, Stagg BC, SOURCE Consortium.   +7 more
europepmc   +1 more source

Optimal tooth brushing initiation age and frequency for preventing early childhood caries: a systematic review and meta-analysis. [PDF]

BMC Oral Health
Al-Sharani HM, Stormon N, Al-Hutbany N, Zhang Y, Zulfiqar T.   +4 more
europepmc   +1 more source