Results 171 to 180 of about 15,949,907 (242)

Targeting CD300a Signaling With a Phosphatidylserine‐Presenting Hydrogel Rescues Macrophage Dysfunction and Accelerates Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the proposed mechanism: PEG/RGD‐PSLs mimic apoptotic cells to engage PS receptors (notably CD300a), transducing an inhibitory signal that suppresses the MyD88/NF‐κB pathway, leading to global anti‐inflammatory and pro‐reparative effects.
Lele Wu, Xuetong Hao, Yang Zou, Xinglin Chen, Junyan Kong, Chunning Gu, Wenjie Ma, Zhongjun Yang, Huifen Liu, Mengmeng Liu, Xin Tong   +10 more
wiley   +1 more source

Engineered Nanoplatforms Targeting Activated Hepatic Stellate Cells for Liver Fibrosis Therapy via TGF‐β Axis Inhibition and Ferroptosis Induction

Advanced Healthcare Materials, EarlyView.
FeS‐VA@lanifibranor (FVL), an activated hepatic stellate cell (aHSC)‐targeted nanoplatform comprising vitamin A‐functionalized two‐dimensional iron sulfide nanosheets and lanifibranor, is engineered for precision therapy of liver fibrosis. FVL suppresses the TGF‐β signaling pathway by inhibiting SMAD2/3 phosphorylation and induces ferroptosis in aHSCs,
Yinuo Yang, Mengyao Mu, Ke Ren, Hui Liu, Pengju Ma, Yingqi Wang, Mengmeng Zhang, Xueli Xu, Wenzhe Li, Wenshuang Gao, Xiao Sun, Qiang Zhu   +11 more
wiley   +1 more source

Global, regional, and national estimates of hepatitis C virus (HCV) infection incidence among people who inject drugs and number of new annual HCV infections attributable to injecting drug use: a multi-stage analysis. [PDF]

Lancet Gastroenterol Hepatol
Artenie A, Trickey A, Looker KJ, Stone J, Lim AG, Fraser H, Degenhardt L, Dore GJ, Grebely J, Cunningham EB, Hazarizadeh B, Low-Beer D, Luhmann N, Webb P, Hickman M, Vickerman P.   +15 more
europepmc   +1 more source

Lifetime prevalence and correlates of self-harm and suicide attempts among male prisoners with histories of injecting drug use. [PDF]

Health Justice, 2018
Stewart AC, Cossar R, Dietze P, Armstrong G, Curtis M, Kinner SA, Ogloff JRP, Kirwan A, Stoové M.   +8 more
europepmc   +1 more source

2‐Deoxyglucose Dendrimer‐Enabled Niclosamide Delivery to FRβ‐Expressing Macrophages Alleviates Endometriosis Progression and Associated Hyperalgesia

Advanced Healthcare Materials, EarlyView.
A folic acid (FA)‐conjugated 2‐deoxyglucose dendrimer selectively targets FRβ+ macrophages in endometriotic lesions, enabling precise intracellular delivery of niclosamide. This nonhormonal nanomedicine enhances drug solubility, provides controlled intracellular release, suppresses lesion growth, reduces inflammation and pain, and establishes FRβ ...
Anubhav Dhull, Mingxin Shi, Madeleine E. Harvey, Taylor M. Page, Rishi Sharma, Kenneth John Goody, Aqib Iqbal Dar, Nash S. Moawad, Vijay Kumar Sirohi, Paul S. Cooke, Kanako Hayashi, Anjali Sharma   +11 more
wiley   +1 more source

Depression, injecting drug use, and risky sexual behavior syndemic among women who inject drugs in Kenya: a cross-sectional survey. [PDF]

Harm Reduct J, 2019
Mwangi C, Karanja S, Gachohi J, Wanjihia V, Ngang'a Z.   +4 more
europepmc   +1 more source

Hydrophilic Polymers Enable Gastrointestinal Transit Monitoring by Fluorine‐19 Magnetic Resonance Imaging

Advanced Healthcare Materials, EarlyView.
Hydrophilic fluorinated copolymers dissolve in chyme and give a strong, single 19F signal, unlike phase‐separating perfluorocarbons. Combined 1H‐19F MRI tracks their whole‐gut transit non‐invasively and without ionizing radiation. In rats, the tracers move through the gastrointestinal tract, resist resorption, and are well tolerated, a proof‐of‐concept
Ondřej Groborz, Vít Herynek, Mária Hovořáková, Zuzana Pavlíková, Linda Dalecká, Klára Steklíková, Petr Matouš, Petr Páral, Margarita Tkachenko, Filip Koucký, Fatma Nalan Cetin, Ludmila Maffei Svobodová, Jiří Beneš, Kristýna Kolouchová   +13 more
wiley   +1 more source

The Prison and Transition Health (PATH) Cohort Study: Study Protocol and Baseline Characteristics of a Cohort of Men with a History of Injecting Drug Use Leaving Prison in Australia. [PDF]

J Urban Health, 2019
Kirwan A, Curtis M, Dietze P, Aitken C, Woods E, Walker S, Kinner S, Ogloff J, Butler T, Stoové M.   +9 more
europepmc   +1 more source

Optical Detection of Cellular Signals at Material Interfaces

Advanced Healthcare Materials, EarlyView.
Emerging functional materials are transforming optical detection of cellular signals. This review highlights optical techniques that exploit the unique optical properties of diverse materials to detect and quantify cellular electrical, chemical, and mechanical signals, and discusses key opportunities and challenges.
Xuchen Ren, Jitong Ren, Zixin Zhang, Koney Eungkon Kim, Francis L. Hong, Yuecheng Peter Zhou   +5 more
wiley   +1 more source

Patterns of Drug and Alcohol Use and Injection Equipment Sharing Among People With Recent Injecting Drug Use or Receiving Opioid Agonist Treatment During and Following Hepatitis C Virus Treatment With Direct-acting Antiviral Therapies: An International Study. [PDF]

Clin Infect Dis, 2020
Artenie AA, Cunningham EB, Dore GJ, Conway B, Dalgard O, Powis J, Bruggmann P, Hellard M, Cooper C, Read P, Feld JJ, Hajarizadeh B, Amin J, Lacombe K, Stedman C, Litwin AH, Marks P, Matthews GV, Quiene S, Erratt A, Bruneau J, Grebely J.   +21 more
europepmc   +1 more source