Results 41 to 50 of about 830,081 (260)
, 2012 The performance of the two types of vapor-injection (VI) cycles in a heat pump system is compared. The vapor-injection cycle using an internal heat exchanger (IHX) has a choice to select the branching point of the injection stream.
Kim, Min Soo, Roh, Chul Woo
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Nitrogen point injection in ridge-till corn
, 1989 Ridge conservation tillage systems are receiving increased attention as an alternative to flat no-till systems for row crop production. A recently-developed fertilizer applicator, the spoke-wheel injector has potential to improve fertilizer-use ...
Blaylock, Alan
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Weakly pointed trees and partial injections
Journal of Symbolic Logic, 2008 AbstractWe define the notion of a weakly pointed tree, and characterize the amount of genericity necessary to prevent a uniformly branching tree being weakly pointed. We use these ideas to show there is no topological analogue of a measure-theoretic selection theorem of Graf and Mauldin.
openaire +3 more sources
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Injection-locked phonon lasing driven by an individual plasmonic metamolecule
, 2017 Nanophotonic devices take advantage of geometry-dependent optical properties to confine and enhance the interaction of light with matter on small scales. By carefully patterning nanoscale geometries, coupling of responses across distinct physical domains
Vladimir A. Aksyuk (3984575) +1 more
core +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
, 2007 Great improvements have been made in engine performance and emission control due to recent intensive research on engine systems. Further improvements are still required and turbocharging is aiding further improvements in emissions, power and downsizing ...
Rao, H.V. +3 more
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