Results 191 to 200 of about 26,232 (250)

DCLK1‐dependent NF‐κB activation mediates p‐STAT3‐induced osteoarthritis progression

open access: yesClinical and Translational Medicine, Volume 16, Issue 6, June 2026.
Doublecortin‐like kinase 1 (DCLK1) is identified as a novel phosphorylated signal transducer and activator of transcription 3 (p‐STAT3) transcriptional target. A novel p‐STAT3/DCLK1/IKKβ/NF‐κB axis regulates chondrocyte extracellular matrix (ECM) metabolism and drives osteoarthritis progression.
Pengfei Li   +7 more
wiley   +1 more source

Polyphenol‐Rich Duhuo Jisheng Decoction Enhances Mesenchymal Stem Cell–Derived Exosome–Mediated Chondroprotection via PI3K/AKT Signaling in Osteoarthritis

open access: yesFood Science &Nutrition, Volume 14, Issue 6, June 2026.
This graphical abstract illustrates the chondroprotective mechanism of exosomes derived from bone marrow mesenchymal stem cells (BMSCs) preconditioned with polyphenol‐rich Duhuo Jisheng Decoction (DHJST‐Exos). Enriched with bioactive compounds such as wogonin, quercetin, and kaempferol, DHJST‐Exos effectively ameliorate osteoarthritis (OA ...
Zhouwei Liao   +9 more
wiley   +1 more source

Overview of the Current Osteoarthritis Treatment in Veterinary Medicine and Future Directions. [PDF]

open access: yesACS Pharmacol Transl Sci
Quintão NLM   +6 more
europepmc   +1 more source

The Role of Hydro-Kinesiotherapy After Intra-Articular Steroid Infiltration in the Management of Juvenile Idiopathic Arthritis: A Non-Randomized Observational Pre-Post Study with Parallel Groups. [PDF]

open access: yesJ Funct Morphol Kinesiol
Gnasso R   +10 more
europepmc   +1 more source

The Role of Endothelin‐1 in Autoimmune Diseases: Mechanistic Insights and Therapeutic Targets

open access: yesiNew Medicine, Volume 2, Issue 2, June 2026.
The Role of Endothelin‐1 in Autoimmune Diseases. NF‐κB: nuclear factor kappa‐B; MAPK: mitogen‐activated protein kinase; PI3K: phosphoinositide 3‐kinase; ROS: reactive oxygen species; CTGF: connective tissue growth factor; TGF‐β: transforming growth factor‐β.
Xun Gong   +5 more
wiley   +1 more source

Impact of Bone Grafting and Graft Type on Fusion and Patient‐Reported Outcomes Following Subtalar Arthrodesis: A Multicenter Retrospective Cohort Study

open access: yesJournal of Foot and Ankle Research, Volume 19, Issue 2, June 2026.
ABSTRACT Background The role of bone grafting in subtalar joint arthrodesis (SJA) remains controversial. This study aimed to compare clinical and radiographic outcomes of SJA performed with and without bone graft and to evaluate the influence of different graft types on fusion and functional results.
Giovan Giuseppe Mazzella   +11 more
wiley   +1 more source

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