Results 41 to 50 of about 26,232 (250)

Intra-articular Injections for Primary Knee Osteoarthritis

, 2022
Osteoarthritis is one of the hundreds of types of arthritis and is the most common type that affects millions of people worldwide. Any joint in the body can be affected, but the most commonly affected is the knee.
Macek, Jenny
core  

Circular RNA circNrip1 Interacts with SYNCRIP to Promote Neuropathic Pain by Stabilizing Tlr2 mRNA in Primary Sensory Neurons

Advanced Science, EarlyView.
Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng, Jifang Xiao, Congcong Huang, Bao‐Chun Jiang, Bing Wang, Xu Li, Shibin Du, Tolga Berkman, Chun‐Hsien Wen, Weihua Cai, Dilip Sharma, Kun Wang, Longfei Ma, Huijuan Hu, Yuan‐Xiang Tao   +14 more
wiley   +1 more source

MR cartilage imaging in assessment of the regenerative power of autologous peripheral blood stem cell injection in knee osteoarthritis

The Egyptian Journal of Radiology and Nuclear Medicine, 2014
Background: Osteoarthritis (OA) describes an age-related, heterogeneous group of disorders characterized pathologically by focal areas of loss of articular cartilage in synovial joints, associated with varying degrees of osteophyte formation, subchondral
Khaled A. Ahmad, Yosra A. Ibrahim, Nayera Z. Saber, Bassem A. Darwish   +3 more
doaj   +1 more source

Feasibility of sonography for intra-articular injections in the knee through a medial patellar portal [PDF]

, 2009
OBJECTIVE: The purpose of this study was to investigate the feasibility of using real-time high-resolution sonography to guide an injection needle into the intra-articular space within the knee.
조성래
core   +1 more source

Intra-articular steroid injections in large joint arthritis: A survey of current practice

, 2022
Introduction: Intra-articular corticosteroid injections are widely used as a management modality for mild large joint osteoarthritis (OA). In contrast, there is little guidance or consensus on the use of steroids in moderate to severe disease. The aim of
Boksh, Khalis, Loumpardias, Georgios, Chong, Han Hong, Eastley, Nicholas   +3 more
core   +1 more source

Intra‑articular injections of platelet‑rich plasma in symptomatic knee osteoarthritis: a consensus statement from French‑speaking experts [PDF]

, 2021
peer reviewedPurpose There has been much debate regarding the use of intra-articular injections of platelet-rich plasma (PRP) as symptomatic treatment for knee osteoarthritis.
Michel, F., Bard, H., Michel, Fabrice, Legré-Boyer, V, Richette, P., Ornetti, Paul, Lamontagne, Martin, Kaux, Jean-François, Noel, É., Bard, Hervé, Allali, Fadoua, Gremeaux, Vincent, Eymard, F, Boyer, Thierry, Kaux, J.F., Allali, F, Richette, Pascal, Gremeaux, V., Maillet, Jérémy, Maillet, J, Maillet, J., Lamontagne, M, Eymard, Florent, Noel, Éric, Ornetti, P., Louati, Karine, Adam, Philippe, Eymard, F., Lamontagne, M., Legré-Boyer, V., Richette, P, Boyer, T., Legré-Boyer, Virginie, Adam, P, Ornetti, P, Gremeaux, V, Louati, K, Bard, H, Louati, K., Adam, P., Boyer, T, Michel, F, Noël, E, Allali, F.   +43 more
core   +1 more source

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Do preoperative intra-articular injections of corticosteroids or hyaluronic acid increase the risk of infection after total knee arthroplasty? A meta-analysis

Bone & Joint Research, 2022
Aims There is conflicting evidence on the safety of intra-articular injections of hyaluronic acid (HA) or corticosteroids (CSs) before total knee arthroplasty (TKA).
Xurong Yang, Li Li, Xiaonan Ren, Lixiong Nie   +3 more
doaj   +1 more source

Bioadhesive Hydrogel With Polyphenol‐Armored Nanogene Rejuvenates Chondrocyte Senescence for Aged Osteoarthritis Therapy

Advanced Science, EarlyView.
An adhesive hydrogel depot with polyphenol‐armored nanogenes is developed for treating aged osteoarthritis. This system maintains miR‐140 bioactivity, prolongs its intra‐articular retention, and enhances transfection into chondrocytes, leading to the downregulation of senescence‐associated pathways.
Liwei Yan, Runze Yang, Ting Zhou, Tianhao Xu, Yongqi Li, Yuelin Hu, Minghao Ge, Lei Zhang, Xiong Lu, Chaoming Xie, Weili Fu   +10 more
wiley   +1 more source