Histamine infusions induce reproducible severe hypotension. Intramuscular adrenaline showed ‘supposedly therapeutic’ plasma concentrations but did not produce a sustained clinically relevant improvement in shock in the majority of recipients. These findings question adrenaline pharmacokinetic surrogate thresholds and support the need for faster and ...
Matthias Weiss‐Tessbach +12 more
wiley +1 more source
From Needle to Necrosis: A Case Report on Nicolau Syndrome. [PDF]
A R, Ssk A, Swaminathan A.
europepmc +1 more source
Hypersensitivity to Excipients in Drugs: An EAACI Position Paper
ABSTRACT Drugs contain active pharmaceutical ingredients and excipients, compounds which enhance the pharmacokinetics, stability and palatability of the pharmaceutical formulation. While most drug hypersensitivity reactions (DHR) are caused by active ingredients, excipients may also be involved.
Lene H. Garvey +10 more
wiley +1 more source
Evaluation of the efficacy of manual pressure and local cold spray application in reducing pain caused by human anti-D immunoglobulin injection in pregnant women: a randomized controlled study. [PDF]
Coşkun ÜG, Coşkuner Potur D.
europepmc +1 more source
Muscle Strength and Power Changes With Gender‐Affirming Hormone Therapy
ABSTRACT Background Androgen receptors are highly expressed in upper body muscles, but changes in maximal muscle strength and power in major upper body muscles have not been investigated during gender‐affirming hormone therapy (GAHT). Objective To assess prospective changes in maximal muscle strength and muscle power from before and after 1 year of ...
Mathilde Kamp Nørlund +12 more
wiley +1 more source
Vitamin B12 desensitization and provocation: Ten-year clinical experience. [PDF]
Dindar Çelik F +7 more
europepmc +1 more source
Vaccinations During Pregnancy Protect the Mother–Infant Dyad and Are Generally Safe
ABSTRACT Aim Vaccination in pregnancy has a critical impact on mothers, foetuses and infants. The aim of this paper was to summarise key points presented by experts attending the 12th Maria Delivoria‐Papadopoulos Perinatal Symposium in March 2025 and further expand and update them.
Ariadne Malamitsi‐Puchner +2 more
wiley +1 more source
Fe(II) with Tris(1-pyrazolyl)methane Complex Increases Thermal Stability In Vitro and Activity In Vivo of the Mutant 447R Form of Mouse Tryptophan Hydroxylase 2. [PDF]
Terentieva EI +7 more
europepmc +1 more source
Scrotal Botulinum Toxin Exposure and Male Fertility: Mechanistic Insights and Clinical Evidence. [PDF]
Azeem A +5 more
europepmc +1 more source
Evaluation of the appropriateness of antimicrobial use requires multiple data elements, including the indication for treatment, duration of therapy and dose of the drug used. To calculate the dose the volume of active ingredient and animal weight are required.
L Hardefeldt, K Li, K Bailey
wiley +1 more source

