Results 41 to 50 of about 59,775 (248)

Ionizable Lipid‐Dependent Optimization of Steroid Lipid Nanoparticles With Tunable Immunomodulatory Properties

Advanced Materials, EarlyView.
A novel engineering strategy that establishes material design principles for incorporating anti‐inflammatory steroids into lipid nanoparticles to reduce LNP‐induced inflammation while retaining mRNA delivery. Results are validated in vitro and in three animal models of inflammation and autoimmunity in vivo.
Ajay S. Thatte, Benjamin E. Nachod, Julia Baena, Jenna Muscat‐Rivera, Lesley Chaboub, Hannah C. Safford, Hannah C. Geisler, Hannah M. Yamagata, Melgious J. Y. Ang, Michael Kegel, Alexandre Poirier, Elaine R. Tong, Zhe Zhong, Qiangqiang Shi, Jinjin Wang, Elisa Battistini, Ye Zeng, Alex G. Hamilton, Kelsey L. Swingle, Drew Weissman, Jilian R. Melamed, Michael J. Mitchell   +21 more
wiley   +1 more source

Multipl MRSA Absesses Following Intramuscular Injection a Case Report

Namık Kemal Tıp Dergisi
Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) cases are rarely reported. In this article, we present a patient who had no history of disease or risk factors for MRSA but developed multiple MRSA abscesses after receiving ...
Bahar Büşra ÖZKAN, Özgür GÜNAL, Hatice ÜDÜRGÜCÜ, Süleyman Sırrı KILIÇ   +3 more
doaj   +1 more source

A First Semimanual Device for Clinical Intramuscular Repetitive Cell Injections

Cell Transplantation, 2010
Intramuscular cell transplantation in humans requires so far meticulous repetitive cell injections. Performed percutaneously with syringes operated manually, the procedure is very time consuming and requires a lot of concentration to deliver the cells ...
Pierre-Luc Richard, Clément Gosselin, Thierry Laliberté, Martin Paradis, Marlyne Goulet, Jacques P. Tremblay, Daniel Skuk M.D.   +6 more
doaj   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

ESTUDO EXPERIMENTAL DAS RELAÇÕES TECLDUAIS EM RATOS, PROVOCADAS POR DIFERENTES CONCENTRAÇÕES DE PENICILINA G. BENZATINA

Revista da Escola de Enfermagem da USP
A procura de respostas científicas aos problemas decorrentes de procedimentos que envolvem ações profissionais constituem um desafio constante aos enfermeiros comprometidos com a melhoria do cuidado de enfermagem.
Mara Rita Rodrigues Massad, Eduardo Massad, Edna Apparecida Moura Arcuri   +2 more
doaj   +1 more source

Self‐Assembling Copolymers Encapsulating Single Endothelial Cells Induce Endogenous ECM Deposition and Vascular Regeneration

Advanced Materials, EarlyView.
This study presents the first demonstration of stable sub‐50‐micron single‐cell GPM vesicles fabricated through the intrinsic self‐assembly of an amphiphilic copolymer. Hierarchical assembly of cell containing GPM vesicles into microspheres enable tunable, sustained cell delivery with immune protection.
Viola B. Morris, Sangho Lee, Kalp Soni, Simon He, Matthew Huang, Dandan Chen, Dae Hoon Lee, Kyung Hee Kim, Seonggeon Cho, Laura Pencea, Divit Jain, Young‐Sup Yoon   +11 more
wiley   +1 more source

A Rat Muscle Pain Model Based on Intramuscular Formalin Injection

Caspian Journal of Neurological Sciences, 2016
Background: Musculoskeletal pain is a major clinical problem, but researchers lack viable animal models to study this phenomenon. However, formalin injections are widely used to produce tonic and neurogenic nociceptive responses in rodents.
Elaheh Erami, Hassan Azhdari-Zarmehri
doaj  

Neuropathy following intramuscular injections: a clinical and neurophysiological study from a tertiary care centre in Pakistan

Journal of the Pakistan Medical Association, 2023
Objective: To assess the clinical and neurophysiological profile of peripheral nerve injuries in patients following intramuscular injections. Method: The descriptive, cross-sectional study was conducted at the Department of Neurology, Mayo Hospital ...
Adnan Tariq, Ayesha Aslam, Nukhbatullah Awan, Safia Bano, Ahsan Numan   +4 more
doaj  

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Adverse reactions of intramuscular injections associated with injection site selection: a literature review

Pielęgniarstwo XXI Wieku
Introduction. This article aims to determine the adverse reactions associated with the application of intramuscular injections at various injection sites. Aim. Our study is the literature review with a systematic search strategy. It includes 11 studies
Eliška Vaníčková, Valérie Tóthová, Sylva Bártlová   +2 more
doaj   +1 more source