Results 211 to 220 of about 140,443 (305)

Subcutaneously Administered Tislelizumab in Locally Advanced or Metastatic Non-Small Cell Lung Cancer: Pharmacokinetics and Safety Results from the BGB-A317-103 Phase I Study. [PDF]

Clin Cancer Res
Chen M, Bulat I, Maglakelidze M, Li N, Chen Z, Kong W, Li Y, Fang J, Zhang J, Zhang J, Wang B, Ma J, Sun Y, Wang Q, Chen X, Liu X, Yu T, Hanley WD, Budha N, Li H, Lin X, Niu Z, Jamal L, Abdrashitov R, Wang M.   +24 more
europepmc   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Stem Cells and Their Derivatives in Cardiac Fibrosis Therapy: Challenges and Perspectives. [PDF]

Cells
Piwowar A, Zolbach Z, Rydzek J, Skonieczna N, Rojek K, Żołyniak M, Soczyńska J, Woźniak S.   +7 more
europepmc   +1 more source

Painful intravenous injections of diazepam [PDF]

Anaesthesia, 1983
openaire   +2 more sources

EEPD1 Inhibition Unleashes Antitumor Immunity in Colorectal Cancer by Activating the cGAS‐STING Pathway

Advanced Science, EarlyView.
In colorectal cancer, high expression of the DNA repair protein EEPD1 correlates with immune exclusion and poor prognosis. This study demonstrates that EEPD1 depletion induces genomic instability, leading to cytosolic DNA accumulation and subsequent activation of the cGAS‐STING‐type I interferon pathway. This cascade remodels the tumor microenvironment
Liyun Huo, Chong Wu, Xiaobo Li, Caina Ma, Jiamin Huang, Zishuo Chen, Weiling He, Tianyu Tao, Weijing Zhang   +8 more
wiley   +1 more source

Whole-body in vivo MPI cytometry reveals injection route-, dose-, cell size-, and disease-dependent differences in organ distribution. [PDF]

Sci Adv
Shakeri-Zadeh A, Kuddannaya S, Chu C, Sood K, Itoo A, Zivko C, Thomas AM, Mahairaki V, Walczak P, Bulte JWM.   +9 more
europepmc   +1 more source

Transdermal Delivery of an mRNA‐Liposome Vaccine via Dissolving Microneedle to Preserve Vaccine Activity and Enhance Immune Activation

Advanced Science, EarlyView.
An mRNA‐liposome vaccine via dissolving microneedles (ML‐DMN) enables efficient skin‐targeted delivery while preserving mRNA integrity and allowing sustained antigen expression. Unlike intramuscular (IM) injection, ML‐DMN engages skin‐resident immune cells, activates antigen‐presenting cells (APCs), and induces strong T cell and cytokine responses at ...
Jeehye Nam, JiWon Ahn, Jiwoo Shin, Nahong Lee, Youjin Lee, Sung min Cho, Paul Kim, Geonwoo Kang, Sang‐Jun Ha, Hyungil Jung   +9 more
wiley   +1 more source

Antibiotic Prescription Practices in Ophthalmology Outpatient Clinics in Khartoum, Sudan: An Observational Cross-Sectional Study. [PDF]

Cureus
Yousif I, Alhassan A, Hamed Ibrahium Badi M, Abdalla Y.   +3 more
europepmc   +1 more source

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

Case Report: Case of severe allergic reaction in a child caused by chlorhexidine skin disinfectant. [PDF]

Front Allergy
Zhao Y, Zhang Y, Kang J, Zhang J, Duan C.   +4 more
europepmc   +1 more source