Results 51 to 60 of about 84,735 (254)

Engineering Nanoplatforms for Alzheimer's Disease Detection via Biomolecular Corona Proteomic and Lipidomic Profiling

Advanced Healthcare Materials, EarlyView.
Engineered nanoparticles capture disease‐specific biomolecular coronas that uncover hidden molecular features of Alzheimer's disease. Combined proteomic and lipidomic analyses reveal a characteristic shift in ribosomal machinery and energy metabolism, generating a multiomic fingerprint that supports accurate disease detection and opens new ...
Antonietta Greco, Roberto Baretta, Andrea Di Fonzo, Andrea Armirotti, Stefano Cinti, Mara Mirasoli, Marco Frasconi, Claudia Corbo   +7 more
wiley   +1 more source

A Lightweight, 3D‐Printable, Low‐Cost, “One‐Click” Dorsal Skin Window for High‐Quality Long‐Term Multimodal Subcutaneous Tumor Imaging

Advanced Healthcare Materials, EarlyView.
An innovative, lightweight 3D‐printed skinfold chamber system is presented for long‐term intravital imaging. This affordable, biocompatible platform simplifies surgical implantation and allows high‐resolution, multimodal visualization of the tumor microenvironment for up to four weeks.
Iván Cortés Domínguez, Xabier Morales Urteaga, Maider Esparza, Lucía Grande, Ainhoa Urbiola, Cristina Ederra, Tomas Muñoz Santoro, Beatrice Pinci, Alvaro Teijeira, Carlos Ortiz de Solórzano   +9 more
wiley   +1 more source

Transforaminal epidural steroid injection under computed tomography guidance in relieving lumbosacral radicular pain

Acta Orthopaedica et Traumatologica Turcica, 2021
Objectives: We analyzed the efficacy of transforaminal epidural steroid injections under computed tomography (CT) in relieving lumbosacral radicular pain due to spinal stenosis.\nMethods: Forty-two patients (7 males, 35 females; mean age 67 years; range ...
Oguz Karaeminogullari, Orcun Sahin, Fatih Boyvat, Rahmi Can Akgun, Utku Gurun, Huseyin Demirors, Ismail Cengiz Tuncay, Reha N. Tandogan   +7 more
doaj  

Mechanically Compliant, Precision‐Porous Brain Implants Reduce the Foreign Body Reaction and Guide Regeneration

Advanced Healthcare Materials, EarlyView.
This study explores how the brain responds to implants of different properties. Hydrogels with various mechanical properties and pore sizes were implanted in adult rat brains. It is observed that hydrogels with mechanical property closely matched to the brain and 40 µm pore size elicit a pro‐healing response from the brain by modulating the immune ...
Ian Dryg, Le Zhen, Rebecca Darrow, Savannah Lawton, Lars Crawford, Robert Robinson, Steve Perlmutter, James D. Bryers, Buddy D. Ratner   +8 more
wiley   +1 more source

The Absence of the Leukotriene B Receptor BLT1 Attenuates Peripheral Inflammation and Spinal Nociceptive Processing Following Intraplantar Formalin Injury

Molecular Pain, 2015
Background Leukotriene B 4 (LTB 4 ) is a potent lipid mediator of inflammation, and its biological effects are mediated primarily through the high affinity LTB 4 receptor BLT1.
Miho Asahara, Nobuko Ito, Takehiko Yokomizo, Motonao Nakamura, Takao Shimizu, Yoshitsugu Yamada   +5 more
doaj   +1 more source

Miniature Soft Robot With Magnetically Reprogrammable Surgical Functions

Advanced Materials, EarlyView.
Miniature soft robots have great prospects to revolutionize minimally invasive treatments. Here we present a miniature soft robot, which can be reprogrammed to perform five surgical functionalities with six‐degrees‐of‐freedom motions. This soft robot can prospectively make minimally invasive surgery considerably safer and painless, and enable ...
Chelsea Shan Xian Ng, Yu Xuan Yeoh, Nicholas Yong Wei Foo, Keerthana Radhakrishnan, Guo Zhan Lum   +4 more
wiley   +1 more source

Ultrasound-guided caudal epidural injection to treat symptoms of lumbar spinal stenosis: a retrospective study

European Journal of Translational Myology
Lumbar spinal stenosis (LSS) occurs when bony, ligamentous, and synovial elements of the lower axial spine degenerate and overgrow, compressing neural and vascular elements in the spinal canal.
Veronica Gagliardi, Antonello Lovato, Francesco Ceccherelli, Giuseppe Gagliardi   +3 more
doaj   +1 more source

Recent Advances in Ferrite‐Based Materials for Biomedical Applications: A Comprehensive Review

Advanced Materials, EarlyView.
Ferrite nanoplatforms are presented as tunable biomedical materials in which synthesis control, cation engineering, defect/morphology regulation, and surface functionalization govern structure–property–bioactivity relationships. These design strategies enable multifunctional applications including MRI contrast, magnetic hyperthermia, targeted drug ...
Pramod D. Mhase, Varsha C. Pujari, Akash V. Fulari, Sunil M. Patange, Sean Li, Danyang Wang, Sagar E. Shirsath   +6 more
wiley   +1 more source

Are joint and soft tissue injections painful? Results of a national French cross-sectional study of procedural pain in rheumatological practice

BMC Musculoskeletal Disorders, 2010
Background Joint, spinal and soft tissue injections are commonly performed by rheumatologists in their daily practice. Contrary to other procedures, e.g.
Poncet Coralie, Laroche Françoise, Perrot Serge, Marie Pierre, Payen-Champenois Catherine   +4 more
doaj   +1 more source

Ionizable Lipid‐Dependent Optimization of Steroid Lipid Nanoparticles With Tunable Immunomodulatory Properties

Advanced Materials, EarlyView.
A novel engineering strategy that establishes material design principles for incorporating anti‐inflammatory steroids into lipid nanoparticles to reduce LNP‐induced inflammation while retaining mRNA delivery. Results are validated in vitro and in three animal models of inflammation and autoimmunity in vivo.
Ajay S. Thatte, Benjamin E. Nachod, Julia Baena, Jenna Muscat‐Rivera, Lesley Chaboub, Hannah C. Safford, Hannah C. Geisler, Hannah M. Yamagata, Melgious J. Y. Ang, Michael Kegel, Alexandre Poirier, Elaine R. Tong, Zhe Zhong, Qiangqiang Shi, Jinjin Wang, Elisa Battistini, Ye Zeng, Alex G. Hamilton, Kelsey L. Swingle, Drew Weissman, Jilian R. Melamed, Michael J. Mitchell   +21 more
wiley   +1 more source