Results 21 to 30 of about 204,304 (200)
Making the Case for Organ‐on‐Chip Platforms in Long‐Acting Therapeutics Development
LATs release drug from a tissue‐resident depot over weeks to months, improving adherence, but their development is hampered by preclinical models that cannot reproduce the coupled tissue processes, sustained release, local microenvironment change, interstitial transport, immune and foreign‐body responses, and clearance that govern depot performance in ...
Charlie Gowans +7 more
wiley +1 more source
A closed U‐shaped microfluidic platform symmetrically embeds a single, size‐controlled HT29 colorectal cancer spheroid within a GFP‐HUVEC‐laden fibrin matrix. HT29 spheroids are associated with hyper‐branched endothelial network remodeling, while vascularized co‐culture is accompanied by anisotropic protrusive growth and EMT‐like marker changes in the ...
G. Cretti +4 more
wiley +1 more source
Injective hulls as completions [PDF]
A preliminary attempt is made to place the theory of completions of boolean algebras and of partially ordered sets in a wider context. The theory and construction of injective hulls in abelian categories is generalised and it is demonstrated that any variety with enough injectives admits injective hulls.
openaire +1 more source
The Interpolative Ideal of Bloch Mappings
Inspired by the interpolative ideal procedure for linear operators due to Matter, the concept of interpolative ideals of a Banach normalized Bloch ideal IB∧ is introduced.
D. Achour +2 more
doaj +1 more source
Injective Hulls of Infinite Totally Split-Decomposable Metric Spaces
We extend the theory of splits in finite metric spaces to infinite ones. Within this more general framework, we investigate the class of spaces having metrics that are integer-valued and totally split-decomposable, as well as the polyhedral complex ...
Maël Pavón
doaj +1 more source
Sustainable Materials Design With Multi‐Modal Artificial Intelligence
Critical mineral scarcity, high embodied carbon, and persistent pollution from materials processing intensify the need for sustainable materials design. This review frames the problem as multi‐objective optimization under heterogeneous, high‐dimensional evidence and highlights multi‐modal AI as an enabling pathway.
Tianyi Xu +8 more
wiley +1 more source
Injective modules over commutative noetherian rings [PDF]
This thesis examines the structure of injective modules over commutative noetherian rings. The author shows that any injective module over a commutative noetherian ring can be written as a direct sum of indecomposable injective modules, where each ...
Staton, James Brooks +1 more
core
Human neutrophils exist as two epigenetically imprinted subtypes defined by stable CD177 expression or absence — a ratio that persists across time, circadian rhythms, and inflammation. CD177− neutrophils display a distinct molecular landscape enriched in arginase 1 and lipid metabolism markers, accumulate in head‐and‐neck tumors, and associate with ...
Marcel Jung +39 more
wiley +1 more source
Global Warming and Mass Extinctions Associated With Large Igneous Province Volcanism
Exploring the links between Large Igneous Provinces and dramatic environmental impact
An emerging consensus suggests that Large Igneous Provinces (LIPs) and Silicic LIPs (SLIPs) are a significant driver of dramatic global environmental and biological changes, including mass extinctions.
David P. G. Bond, Yadong Sun
wiley +1 more source
Rational engineering of terminal substituents in symmetric azobenzene‐based molecules enables precise control over conformationally coupled charge‐transfer processes. This design yields tunable nonvolatile resistive memory behaviors, ranging from write‐once‐read‐many‐times (WORM) to rewritable switching.
Yanze Liu +11 more
wiley +1 more source

