Results 81 to 90 of about 1,867,682 (297)

Facing Facts: Facial Injuries from Stand-up Electric Scooters [PDF]

, 2020
Background Stand-up electric scooters (SES) are a popular public transportation method. Numerous safety concerns have arisen since their recent introduction.
Alwani, Mohamedkazim, Bandali, Elhaam, Jones, Alexander J., Lancaster, Benjamin, Sandelski, Morgan, Shipchandler, Taha, Sim, Michael W., Ting, Jonathan   +7 more
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Sports Injury Prevention in Danbury, CT [PDF]

, 2017
Sports Injuries, especially overuse injuries, cause a significant amount of morbidity and public health cost, especially for young athletes. Importantly, many of these injuries can be prevented with proper training and some novel approaches to warm-up ...
Polonski, Cori
core   +1 more source

Prediction of survival probabilities with Bayesian Decision Trees [PDF]

, 2013
Practitioners use Trauma and Injury Severity Score (TRISS) models for predicting the survival probability of an injured patient. The accuracy of TRISS predictions is acceptable for patients with up to three typical injuries, but unacceptable for patients
Bailey, Becalick, Bishop, Bouamra, Boyd, Breiman, Chawda, Chipman, Chipman, Clermont, Denison, Dietterich, DiRusso, Domingos, Duda, Green, Hadfield, Hall, Hilden, Hunter, Jaimes, Jakaite, Kilgo, Kilgo, Koshy, Kreke, Krzanowski, Kuncheva, Li, Livia Jakaite, Lunn, Millham, Oakland, Osler, Osler, Patil, Quinlan, Robert, Rogers, Rogers, Schetinin, Schetinin, Schetinin, Schetinin, Silva, Steyerberg, Stojadinovic, Sujin, Vapnik, Vitaly Schetinin, Wojtek J. Krzanowski   +50 more
core   +2 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

New Zealand bicycle helmet law - do the costs outweigh the benefits? [PDF]

, 2002
Objectives: This paper examines the cost effectiveness of the compulsory bicycle helmet wearing low (HWL) introduced in New Zealand on 1 January 1994. The societal perspective of costs is used for the purchase of helmets and the value of injuries averted.
Scuffham, P., Taylor, M.
core   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

The Pattern of Oral and Maxillofacial Injuries Among Patients Attending Muhimbili National Hospital, Dar es salaam, Tanzania [PDF]

, 2012
To determine the pattern of oral and maxillofacial injuries among patients attended at the Muhimbili National Hospital, Dar es Salaam, Tanzania. Descriptive cross-sectional hospital based study.
Kileo, Baraka Fredrick
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

WSES classification and guidelines for liver trauma [PDF]

, 2016
The severity of liver injuries has been universally classified according to the American Association for the Surgery of Trauma (AAST) grading scale. In determining the optimal treatment strategy, however, the haemodynamic status and associated injuries ...
Abu-Zidan, Fikri M., Ansaloni, Luca, Biffl, Walter, Catena, Fausto, Ceresoli, Marco, Coccolini, Federico, Coimbra, Raul, Fraga, Gustavo, Ivatury, Rao, Kluger, Yoram, Montori, Giulia, Moore, Ernest E., Moore, Frederick A., Naidoo, Noel, Peitzman, Andrew, Rizoli, Sandro, Sartelli, Massimo, Weber, Dieter, Zanini, Nicola   +18 more
core   +2 more sources