Results 101 to 110 of about 8,351,722 (333)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Focused Assessment with Sonography in Trauma for Assessment of Injury in Military Settings: A Meta-analysis

Balkan Medical Journal, 2020
Background:Non-invasive, rapid, and precise assessment of injury in the military settings is extremely important, yet difficult. Focused assessment with sonography in trauma (FAST) is being increasingly employed for assessing the location and severity of
Xingshun Qi, Jing Tian, Rui Sun, He Zhang, Jinsong Han, Hai Jin, Hui Lu   +6 more
doaj   +1 more source

Arabic translation and cross-cultural adaptation of Sport Concussion Assessment Tool 5 (SCAT5)

Biology of Sport, 2020
The aim was to create a Modern Standard Arabic SCAT5 version for different Arabic dialects. This translation and cross-cultural adaptation was performed in eight stages: initial translations, reconciliation of translations and cultural adaptation, back ...
Louis J. Holtzhausen, Sofiane Souissi, Omar Al Sayrafi, Awartani May, Abdulaziz Farooq, Catharina C. Grant, Vasileios Korakakis, Safia Rabia, Souhaila Segers, Karim Chamari   +9 more
doaj   +1 more source

Classification of lower extremity movement patterns based on visual assessment: reliability and correlation with 2-dimensional video analysis [PDF]

, 2014
CONTEXT: Abnormal movement patterns have been implicated in lower extremity injury. Reliable, valid, and easily implemented assessment methods are needed to examine existing musculoskeletal disorders and investigate predictive factors for lower extremity
Graci, Valentina, Harris-Hayes, Marcie, Koh, Christine, Royer, Nathaniel K, Salsich, Gretchen B, Steger-May, Karen   +5 more
core   +2 more sources

Assessment of Follow-up Care After Emergency Department Presentation for Mild Traumatic Brain Injury and Concussion

JAMA Network Open, 2018
Key Points Question Do patients with mild traumatic brain injury (mTBI) receive adequate levels of follow-up care? Findings In a cohort study using data on 831 patients with mTBI presenting to the emergency department at 1 of 11 level I trauma centers ...
S. Seabury, É. Gaudette, D. Goldman, A. Markowitz, J. Brooks, M. McCrea, D. Okonkwo, G. Manley, O. Adeoye, N. Badjatia, Kim Boase, Yelena G. Bodien, M. Bullock, R. Chesnut, J. Corrigan, K. Crawford, R. Diaz-Arrastia, S. Dikmen, A. Duhaime, R. Ellenbogen, V. Feeser, Adam R Ferguson, B. Foreman, Raquel C Gardner, J. Giacino, Luis Gonzalez, S. Gopinath, R. Gullapalli, J. Hemphill, G. Hotz, Sonia Jain, F. Korley, J. Kramer, Natalie P. Kreitzer, H. Levin, C. Lindsell, J. Machamer, C. Madden, Alastair J. Martin, T. McAllister, Randall E. Merchant, P. Mukherjee, L. Nelson, Florence Noel, E. Palacios, D. Perl, A. Puccio, Miri Rabinowitz, C. Robertson, J. Rosand, A. Sander, Gabriella Satris, David M Schnyer, M. Sherer, M. Stein, Sabrina R. Taylor, N. Temkin, A. Toga, A. Valadka, M. Vassar, P. Vespa, Kevin K. W. Wang, J. Yue, E. Yuh, R. Zafonte   +64 more
semanticscholar   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Establishment of Health Technology Assessment in Iran

Journal of Family and Reproductive Health, 2012
Objective: Health Technology Assessment (HTA) aims at informing healthcare policymakers, managers and practitioners of the "clinical consequences, but also the economic, ethical, and other social implications of the diffusion and use of a specific ...
Shila Doaee, Alireza Oliyaeemanesh, Mina Nejati, Mohamadreza Mobinizadeh, Parisa Aboee, Seyed Hasan Razavi   +5 more
doaj  

Longitudinal Optogenetic Motor Mapping Revealed Structural and Functional Impairments and Enhanced Corticorubral Projection after Contusive Spinal Cord Injury in Mice [PDF]

, 2019
Current evaluation of impairment and repair after spinal cord injury (SCI) is largely dependent on behavioral assessment and histological analysis of injured tissue and pathways. Here, we evaluated whether transcranial optogenetic mapping of motor cortex
Chai, Zhi, Jin, Xiaoming, Qian, Jun, Wu, Wei, Xiong, Wenhui, Xu, Xiao-Ming   +5 more
core   +1 more source

Ultrasound elastography: compression elastography and shear-wave elastography in the assessment of tendon injury

Insights into Imaging, 2018
Ultrasound elastography (USE) is a recent technology that has experienced major developments in the past two decades. The assessment of the main mechanical properties of tissues can be made with this technology by characterisation of their response to ...
Rui Prado-Costa, João Rebelo, João Monteiro-Barroso, A. Preto   +3 more
semanticscholar   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source