Results 51 to 60 of about 4,603,261 (388)

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Recurrent violent injury: magnitude, risk factors, and opportunities for intervention from a statewide analysis. [PDF]

, 2016
INTRODUCTION: Although preventing recurrent violent injury is an important component of a public health approach to interpersonal violence and a common focus of violence intervention programs, the true incidence of recurrent violent injury is unknown ...
Crandall, Marie L., Delgado, M. Kit, Ebler, David J., Kaufman, Elinore, Rising, MD, MS, Kristin L., Wiebe, Douglas J.   +5 more
core   +2 more sources

Recommendations for hamstring injury prevention in elite football: translating research into practice

British Journal of Sports Medicine, 2018
Injuries in football exert negative impacts on team performance1 and club finance.2 Hamstring strain injuries (HSI) are consistently the most prevalent time loss injury in football3 and as such are an important issue in football medicine. Despite an ever-
Matthew Buckthorpe, S. Wright, S. Bruce-Low, G. Nanni, T. Sturdy, A. Gross, Laura Bowen, Bill Styles, S. Della Villa, Michael Davison, M. Gimpel   +10 more
semanticscholar   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Efficacy of the Protocol for Trauma Team Activation in Taipei: A Retrospective Study

Emergency Medicine International
Conclusion: The Taipei prehospital field triage guidelines are acceptable but not an ideal tool for identifying patients with major trauma, with an overtriage rate of 48.12% and an undertriage rate of 12.03%.
Wan-Lin Chen, Ju-Chi Ou, Shih-Yu Ko, Wen-Ching Li, Hon-Ping Ma   +4 more
doaj   +1 more source

Using opinion leaders to address intervention gaps in concussion prevention in youth sports: key concepts and foundational theory

Injury Epidemiology, 2018
Behavioral interventions to increase disclosure and proper management of concussion in youth sports have unrealized potential when it comes to preventing concussion. Interventions have focused on changing individual athlete behavior and have fallen short
Zachary Y. Kerr, Johna K. Register-Mihalik, Juliet Haarbauer-Krupa, Emily Kroshus, Vivian Go, Paula Gildner, K. Hunter Byrd, Stephen W. Marshall   +7 more
doaj   +1 more source

Sports Injury Prevention in Danbury, CT [PDF]

, 2017
Sports Injuries, especially overuse injuries, cause a significant amount of morbidity and public health cost, especially for young athletes. Importantly, many of these injuries can be prevented with proper training and some novel approaches to warm-up ...
Polonski, Cori
core   +1 more source

Opinions, Barriers, and Facilitators of Injury Prevention in Recreational Runners.

Journal of Orthopaedic and Sports Physical Therapy, 2019
STUDY DESIGN Comparative cross-sectional study. BACKGROUND Effective injury prevention measures for running-related injuries (RRIs) have not yet been identified.
Tryntsje Fokkema, R. de Vos, S. Bierma-Zeinstra, M. van Middelkoop   +3 more
semanticscholar   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Primary care providers' discussion of fall prevention approaches with their older adult patients—DocStyles, 2014

Preventive Medicine Reports, 2018
Falls are the leading cause of fatal and non-fatal injuries among older adults. The American and British Geriatric Societies recommend a fall risk assessment to identify risk factors and guide interventions to prevent these falls.
Elizabeth R. Burns, Yara K. Haddad, Erin M. Parker   +2 more
doaj   +1 more source