Results 11 to 20 of about 5,541 (189)
Pharmacokinetic-pharmacodynamic model of urinary δ-aminolevulinic acid reduction after givosiran treatment in patients with acute hepatic porphyria. [PDF]
CPT Pharmacometrics Syst Pharmacol, 2023 Abstract Givosiran, an RNA interference‐based therapeutic, is a recent addition to the limited treatment armamentarium for acute hepatic porphyria (AHP). As a small interfering RNA that is selectively taken up in the liver, both the mechanism and targeted delivery create a complex relationship between givosiran pharmacokinetics (PK) and the ...
Lee J, Melch M, Robbie GJ.
europepmc +2 more sources
Electrochemical Sensor Based on Black Phosphorus for Antimony Detection Using Dip-Pen Nanolithography: The Role of Dwell Time. [PDF]
Small MethodsMeta‐chemical surfaces based on black phosphorus (BP) are developed for electrochemical Sb(III) sensing using dip‐pen nanolithography. The surface‐to‐volume ratio and the fill factor, which can be altered by the dwell time, affect the detection limit.
Yadav KK +5 more
europepmc +2 more sources
Dip-Pen Nanolithography-Based Fabrication of Meta-Chemical Surface for Heavy Metal Detection: Role of Poly-Methyl Methacrylate in Sensor Sensitivity. [PDF]
Small SciMeta‐chemical surface (MCS)‐based 1,8‐diaminonaphthalene and MCS‐based D‐penicillamine are being developed as electrochemical sensors by dip‐pen nanolithography. The surface‐to‐volume ratio and the binding strength between the metals and the ligands affect the sensor sensitivity.
Okbi R +7 more
europepmc +2 more sources
Site-Selective Biofunctionalization of 3D Microstructures Via Direct Ink Writing. [PDF]
SmallA combination of two‐photon lithography with scanning probe lithography is proposed as a new approach for biofunctionalization of 3D microstructures, with spatially controlled biomolecule distribution. The method utilizes a diverse range of biomolecule inks, including phospholipids, and two different proteins, introducing sub‐1 µm resolution and ...
Mathew G +8 more
europepmc +2 more sources
Glucose Oxidase Patterned Meta‐Chemical Surface for Sensing Glucose Using Dip‐Pen Nanolithography
ChemElectroChem, Volume 10, Issue 24, December 13, 2023., 2023 Meta‐chemical surface (MCS) electrode‐based biosensors were developed by using dip‐pen nanolithography (DPN). The DPN enables control over the sizes of and distances between the patterned clusters, which control glucose detection sensitivity and efficiency.
Dganit Saban +3 more
wiley +1 more source
Advanced Engineering Materials, Volume 25, Issue 12, June 2023., 2023 Closed‐loop control is demonstrated for aerosol jet printing by integrating light scattering measurements of the aerosol stream with custom printer software. This system allows quantitative approaches to ink development and fundamental process studies, and supports more consistent and direct control of the deposition rate to support more reliable ...
Jeremy D. Rurup, Ethan B. Secor
wiley +1 more source
A Nucleophilic Activity‐Based Probe Enables Profiling of PLP‐Dependent Enzymes
ChemBioChem, Volume 24, Issue 7, April 3, 2023., 2023 The first activity‐based probe for PLP‐dependent enzymes is reported. The trifunctional probe contains an N‐hydroxyalanine warhead, a linear diazirine, and an alkyne to enable enrichment. The essential protein LysA was identified as the primary target of the probe.
Scott I. Brody +7 more
wiley +1 more source
3D Nanolithography by Means of Lipid Ink Spreading Inhibition
Small, Volume 19, Issue 10, March 8, 2023., 2023 Starting from a fluid phase phospholipid ink, 3D patterning is achieved using dip‐pen nanolithography. Pre‐coated Serum Albumin on the surfaces yield unprecedented phospholipid ink spreading inhibition, which enables thickness coordinate control capacity through the writing parameters, namely writing speed and relative humidity. The final metallization
Eider Berganza +7 more
wiley +1 more source
Prussian Blue: Chemistry, Commerce, and Colour in Eighteenth‐Century Paris
Art History, Volume 46, Issue 1, Page 154-186, February 2023., 2023 This essay reconsiders the story of a pigment. Prussian blue, discovered at the beginning of the eighteenth century, is often described as a revolutionary colour that instantly transformed painters’ palettes and practices. Grounded in a ‘thick description’ of the pigment's history in Paris, this article challenges the legendary account of Prussian blue
Charlotte Guichard +2 more
wiley +1 more source