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The Nuclear Receptor NR1B1/RARα Arrests the Differentiation of Anti‐Tumor Effector Cytotoxic T Cells

Advanced Science, EarlyView.
RARα is highly expressed by differentiated effector and exhausted T cells and exerts a negative effect on effector T cell differentiation and the associated trafficking receptor switch. Upregulated RARα levels decrease the nuclear histone acetylase (HAT) activity, and this suppresses the expression of key Teff transcription factor BATF and trafficking ...
Patrick Niekamp, Ryun Hee Kim, Adithyan Jayaraman, Nils Klement, Raymond Kostlan, Chang H. Kim   +5 more
wiley   +1 more source

Trained innate immunity attenuates macrophage efferocytosis of cancer cells

Chatzis A, Lukaszonek J, Lagos D, Boucher D, Kourtzelis I.   +4 more
europepmc   +1 more source

Editorial: Innate immunity in vasculitis. [PDF]

Front Immunol
De Souza AWS, Ooi JD, Misra DP, Zhong Y, Brown KL.   +4 more
europepmc   +1 more source

Innate Immunity and Acqired Immunity

Journal of Nippon Medical School, 2002
openaire   +4 more sources

Pangolin scales as adaptations for innate immunity against pathogens. [PDF]

BMC Biol
Tian X, Chen L, Zhou J, Wang E, Wang M, Jakubovics N, Li J, Song K, Lau KT, Koepfli KP, Zhang S, Tan GYA, Yang Y, Choo SW.   +13 more
europepmc   +1 more source

PGLYRP2 drives hepatocyte-intrinsic innate immunity by trapping and clearing hepatitis B virus. [PDF]

J Clin Invest
Li Y, Ma H, Zhang Y, He T, Li B, Ren H, Feng J, Sheng J, Li K, Qian Y, Wang Y, Zhao H, He J, Li H, Wu H, Yao Y, Shi M.   +16 more
europepmc   +1 more source

Unconventional posttranslational modification in innate immunity. [PDF]

Cell Mol Life Sci
Chen J, Qi D, Hu H, Wang X, Lin W.
europepmc   +1 more source

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Innate Immunity

Pediatric Clinics of North America, 2019
The innate immune response system forms an important line of defense by deploying a limited number of receptors specific for conserved microbial components. This deployment generates a rapid inflammatory response, while activating the adaptive immune system.
Bani Preet, Kaur, Elizabeth, Secord
openaire   +3 more sources