XIAP Stabilizes DDRGK1 to Promote ER‐Phagy and Protects Against Noise‐Induced Hearing Loss
Advanced Science, EarlyView.Mechanism of GAS‐mediated protection against noise‐induced hearing loss (NIHL). Noise exposure activates the ATF4/eIF2α axis, downregulating XIAP and promoting DDRGK1 degradation, thereby inhibiting ER‐phagy and leading to hair cell (HC) death. GAS treatment rescues XIAP and DDRGK1 expression, reactivating ER‐phagy to mitigate HC loss, synaptic damage,
Lin Yan +13 more
wiley +1 more source
Internal Speech in Natural Discourse Communication: A Systematic Review and Modeling
ПсихолінгвістикаIntroduction. Conditions of the modern informative world, when scientists’ attention is paid to the problems of people’s speech communication in different socionomic spheres in the system «human being is a human being», that is related to speech ...
Лариса Калмикова +4 more
doaj +1 more source
On issues of labelling in the dictionnaire Français–Mpongwé : a case-study [PDF]
, 2009 Dictionaries contain lexicographic data whose occurrence is restricted to certain geo-graphical areas, subject fields, professions, etc. It is part of the duties of the lexicographer to give an account of such deviations to ensure a successful retrieval ...
Mavoungou, Paul Achille
core
Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome
Advanced Science, EarlyView.Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel +19 more
wiley +1 more source
Does novel Coronavirus teach us about meditation? [PDF]
Is Nature teaching us about meditation? The lockdown of people inside their homes forced by the novel Coronavirus gave us a glimpse of what is possible for the restoration of the purity of Nature if humanity stops their ceaseless activity for a length of
Ganesan, Ramakrishnan Angarai
core
Advanced Science, EarlyView.Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao +36 more
wiley +1 more source
Neurophysiological evidence of motor preparation in inner speech and the effect of content predictability. [PDF]
Cereb Cortex, 2023 Chung LK +9 more
europepmc +1 more source
IMPLEMENTING MACHINE LEARNING PARADIGMS FOR DECODING OF INNER SPEECH COMMANDS: AN EEG-BCI STUDY
, 2023 Sahar Jahanikia +8 more
openalex +1 more source
Performance of concatenated Reed-Solomon trellis-coded modulation over Rician fading channels [PDF]
A concatenated coding scheme for providing very reliable data over mobile-satellite channels at power levels similar to those used for vocoded speech is described.
Lodge, John H., Moher, Michael L.
core +1 more source
Connexin 26 Functions as a Direct Transcriptional Regulator During the Cochlea Development
Advanced Science, EarlyView.Connexin26 can not only form intercellular channels that mediate rapid communication on the cell membrane, but also enter the nucleus as a transcription factor to directly regulate the transcription of nuclear genes. In the developing cochlea, Cx26 can control the maturation of the molecular scissor ADAM10 by regulating the transcription of TspanC8 ...
Xiaozhou Liu +8 more
wiley +1 more source