Results 111 to 120 of about 256,764 (360)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Ascetismo e inocência: a questão da religião no Humano, demasiado humano de Nietzsche
Cadernos NietzschePretende-se analisar, neste artigo, a estratégia histórico-fisiopsicológica utilizada por Nietzsche em Humano, demasiado humano no que diz respeito à sua análise da metafísica religiosa e, mais precisamente, do ascetismo. Para isso, demonstraremos como a
Jelson Roberto de Oliveira
doaj
The Reliability of Eyewitness Testimony [PDF]
, 2014 As perhaps the single most effective method of proving the elements of a crime, eyewitness testimony has been vital to the trial process for centuries.
Roberts, Nathan
core +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Conviction of the Innocent; from the Judicial Error to the Real Innocence [PDF]
Faṣlnāmah-i Pizhūhish-i Huqūq-i Kiyfarī, 2014 Wrongful conviction of the innocent is a type of miscarriage of justice. Thus, the perspective that believes these two concepts are equivalent is false. Innocence can be actual or legal. The actual innocent is who does not commit the crime.
Muhammad Farajiha, Jamshid Gholamlou
doaj
Photographs and Labels: Against a Criminology of Innocence [PDF]
, 2006 The American photographer Taryn Simon was inspired by the Innocence Project (which aims to acquit falsely convicted people by introducing evidence that was unavailable during their trial) to begin her own photographic project.
Biber, K
core +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
The Rhetoric of Equality [PDF]
, 1991 The affirmative action debate appears intractable. On one side, those employing the rhetoric of innocence use contemporaneous findings of actual discrimination as the gauge that defines victim status.
Devins, Neal
core +1 more source