Results 141 to 150 of about 263,338 (353)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Innocent Prattle [PDF]

Anesthesiology, 2009
openaire   +2 more sources

Setting the Game of Ferocity and Innocence: Hunts of Jahangir

, 2018
Manisha Choudhary, R Skelton, S Verma, Ebba Koch, Ebba Koch, Shireen Moosvi, Shireen Moosvi, Stephen Markel, Stephen Markel, Ebba Koch, Mahesh Rangarajan, Tuzuk-I Jahangiri, Julie Hughes, ; Jahangiri, ; Jahangiri, Jahangiri, Julie Hughes, ; Jahangiri, ; Jahangiri, ; Jahangiri, ; Jahangiri, Jahangiri, Ebba Koch, Mahesh Rangarajan, Shireen Moosvi, Shireen Moosvi, Stephen Markel, Thomas Aitherr, John Reiger   +28 more
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

The Responsibility of Government for Compensating Arrestees and Convicts in the Time of Innocence and Release in the Kurdistan Region

, 2021
Rdhwan Shareef Salih, Turan Kareem Rasul
openalex   +2 more sources

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Presumption of Innocence in Criminal Procedure

EIRP Proceedings, 2009
Presumption of innocence appears as a rule hardly in modern penal trial. For first timewas noted in legislation from the end of the XVIIIth century (United States of America legislationand Declaration of Human Rights and Citizens in 1789).
Tatiana Zbanca
doaj  

“Labelled a murderer”- A discursive analysis of Amanda Knox’s construction of innocence [PDF]

, 2015
Louise J. White
openalex  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Ascetismo e inocência: a questão da religião no Humano, demasiado humano de Nietzsche

Cadernos Nietzsche
Pretende-se analisar, neste artigo, a estratégia histórico-fisiopsicológica utilizada por Nietzsche em Humano, demasiado humano no que diz respeito à sua análise da metafísica religiosa e, mais precisamente, do ascetismo. Para isso, demonstraremos como a
Jelson Roberto de Oliveira
doaj