Results 81 to 90 of about 6,086 (265)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
ILN Journal: Indian Literary NarrativesThis article explores how the figure of the orphaned child functions as a mediator between the human and the divine, with particular emphasis on the symbolic role of the crucifix as an embodiment of suffering, redemption, and divine compassion. Employing
Dr R. Celin Diana
doaj +1 more source
PROTECTION OF THE INNOCENT. [PDF]
JAMA: The Journal of the American Medical Association, 1906 What is the conclusion to be drawn from the previous papers on this subject? It is, I think, twofold. First, as regards those who assume the role of protectors of innocence: let them beware of their ignorance, for, unhappily, they are not all-wise.
openaire +2 more sources
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
The presumption of innocence in Russian law: theoretical and comparative legal aspects
Russian Studies in Law and PoliticsBackground. The relevance of the study is due to the need for a deep understanding of the essence and significance of the presumption of innocence in modern society, especially in the context of dynamically developing legislation and law enforcement ...
Shamil R. Zaripov +5 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Justitia Et PaxThe presumption of innocence is one of the principles that provides legal protection for suspects and defendants in the process of enforcing criminal law, but there is also a view that states that in the investigation process it would be more appropriate
Manuel Defender Nakamnanu
doaj +1 more source