Chromenone derivatives as CRM1 Inhibitors for Targeting Glioblastoma
Glioblastoma (GBM) is one of the most aggressive and deadly cancers. Due to the complexity and redundancy within signaling networks in GBM, targeted inhibitors of specific pathways have shown only limited success. The nuclear export receptor Chromosome Region Maintenance 1 (CRM1) has recently emerged as a promising therapeutic target, as its inhibition
Wolfgang Link+10 more
wiley +1 more source
'La innovación y el crecimiento de la productividad en España
Elena Huergo, Lourdes Moreno Martín
openalex +1 more source
Integrating ontogenetic and behavioral analysis in fossil and extant Lynx pardinus (Temminck, 1827). [PDF]
Jimenez IJ+6 more
europepmc +1 more source
Perester‐type species on the CO oxidation catalyzed by gold‐based nanoparticles is a key intermediate for efficient catalysis. The high spin electronic state of the Au–Ru cluster favors oxygen molecule barrierless dissociation upon adsorption. Charge accumulation on Ru enhanced by charge transfer enhanced O─O bond activation.
Ana E. Torres+3 more
wiley +1 more source
Emergence of KPC-8-producing <i>K. pneumoniae</i> infection without prior exposure to ceftazidime/avibactam: the threat of <i>de novo</i> infections by ceftazidime/avibactam-resistant KPC variants. [PDF]
Mateo-Vargas MA+5 more
europepmc +1 more source
The efficient and robust enantioselective organocatalytic methodology was developed for the conjugate addition of isoxazol‐5(4H)‐ones to aurone‐derived azadienes. This approach provided products featuring benzofuran and isoxazole rings with high yields and enantioselectivities.
Ricardo Torán+4 more
wiley +1 more source
Mediterranean Diet Patterns Are Positively Associated with Maximal Fat Oxidation and VO<sub>2</sub>max in Young Adults: The Mediating Role of Leptin. [PDF]
Santiago-Arriaza P+9 more
europepmc +1 more source
Pt/TiO2 Prepared by Mechanochemistry Boosts Photocatalytic Production of Hydrogen
Ball milling enables the rapid synthesis of a Pt/TiO₂ photocatalyst with atomically dispersed Pt, outperforming a conventional Pt‐cluster catalyst (1.3× higher H2 evolution from ethanol). Enhanced activity is attributed to single‐atom stabilization and suppressed surface restructuring, promoting efficient charge separation via Schottky barrier ...
Asier Agrelo‐Lestón+2 more
wiley +1 more source
Speckle-Based Transmission and Dark-Field Imaging for Material Analysis with a Laboratory X-Ray Source. [PDF]
Rosich D, Chevalier M, Alieva T.
europepmc +1 more source
First Row Transition Metals in Olefin Metathesis: The Role of Iron and Manganese
Olefin metathesis is primarily a love story with molybdenum and ruthenium, but the dream is to transition to first‐row transition metals, such as manganese and especially iron. Will this be feasible? This work discusses some challenges associated with this migration.
Artur Brotons Rufes+6 more
wiley +1 more source