Results 241 to 250 of about 1,076,889 (376)

Discovering Uncharted Binding Pockets on E3 Ligases Leads to the Identification of FBW7 Allosteric Modulators

Advanced Science, EarlyView.
A computational approach to identify and characterize ligandable binding pockets on E3 ligases is presented. As a validation case, the first low‐micromolar small moleculesthat bind to the FBW7 E3 ligase are identified and confirmed to bind at the intended site.
Míriam Martínez‐Cartró, Álvaro Serrano‐Morrás, Andrea Bertran‐Mostazo, Roger Castaño‐Muñiz, Salvatore Scaffidi, Varbina Ivanova, Noémi Csorba, József Simon, Péter Ábrányi‐Balogh, Yunfeng Li, György M. Keserü, Bing Hao, Xavier Barril, Carles Galdeano   +13 more
wiley   +1 more source

Detección precoz de cáncer de cérvix según los discursos de las matronas de atención primaria en Segovia, España

Revista de Saúde Pública
OBJETIVO: Analizar los discursos de las matronas de atención primaria sobre el acceso y la utilización del Programa Preventivo de Cáncer de Cérvix. PROCEDIMIENTOS METODOLÓGICOS: Se desarrolló un estudio cualitativo en un área de baja densidad poblacional,
Laura Otero, Belén Sanz, Teresa Blasco
doaj  

Reseña del libro: La izquierda uruguaya. Tradición, innovación y política, Caetano, Gerardo ; Gallardo, Javier ; Rilla, José

, 1997
Silvia Dutrénit Bielous
openalex   +2 more sources

Guía Técnica Premio Nacional INDES - BID a la Calidad e Innovación en la Gerencia Social: República Dominicana 2000-2001 [PDF]

, 2002
Alejandro Medina Giopp
openalex   +1 more source

Discovery of a Baloxavir‐Inspired Endonuclease Inhibitor That Prevents Herpes Simplex Virus 1 Replication in Cell Culture and In Vivo

Advanced Science, EarlyView.
Current herpesvirus treatments targeting the viral DNA polymerase are limited by toxicities and drug resistance. Novel compounds inhibiting the nuclease activity of the herpes simplex virus 1 (HSV‐1) terminase complex, required for viral genome packaging, have been identified.
Sabina Andreu, Kai Tang, Jiahui Zhou, Gabriel Pino‐Peco, Nerea López‐Carrobles, Raquel Bello‐Morales, Daniel Galdo‐Torres, Lina Zhang, Federico Gago, José Antonio López‐Guerrero, Xinyong Liu, Peng Zhan, Luis Menéndez‐Arias   +12 more
wiley   +1 more source

Early Oral Administration of D-Chiro-Inositol Reverses Hippocampal Insulin and Glutamate Signaling Deficits in the 3×Tg Humanized Mouse Model of Alzheimer's Disease. [PDF]

Nutrients
Pacheco-Sánchez B, Verheul-Campos J, Vargas A, Tovar R, Rodríguez-Pozo M, Navarro JA, López-Gambero AJ, Baixeras E, Serrano-Castro PJ, Suárez J, Sanjuan C, Rivera P, Rodríguez de Fonseca F.   +12 more
europepmc   +1 more source

La poesía de César Vallejo: Tradición e innovación

, 1999
Marco Martos
openalex   +2 more sources

Co‐Sensitized Solar Cell Achieves 13.7% Efficiency with Bis‐Hexylthiophene Dyes

Advanced Science, EarlyView.
The authors demonstrate that the longer excited state lifetime dye in combination with a copper electrolyte produces a high photovoltage of 1.22 V, owing to retarded interfacial charge recombination. The co‐sensitized solar cell achieves efficiencies of 13.7% under full sunlight and 29.7% under LED light.
Heng Wu, Laia Marín Moncusí, Jing Li, Eugenia Martinez‐Ferrero, Peng Wang, Emilio Palomares   +5 more
wiley   +1 more source

Centenarian athletes: The paradigm of healthy longevity? [PDF]

J Nutr Health Aging
Buendía-Romero Á, Higueras-Liébana E, Alegre LM, Ara I, Valenzuela PL.   +4 more
europepmc   +1 more source

Federalización e innovación educativa en México

, 1999

openalex   +1 more source