Results 91 to 100 of about 148,123 (226)

The Gut Microbiota as a Mediator in the Relationship Between Dietary Patterns and Depression

MedComm, Volume 7, Issue 2, February 2026.
Healthy dietary patterns are associated with gut microbial genera linked to lower depressive symptoms. In 644 older adults from the PREDIMED‐Plus cohort, 16S rRNA sequencing and dietary scoring revealed that taxa associated with a better diet quality were also more abundant in individuals with fewer depressive symptoms.
Adrián Hernández‐Cacho, Jiaqi Ni, Jesús F. García‐Gavilán, Prokopis Konstanti, Clara Belzer, Jesús Vioque, Dolores Corella, Montserrat Fitó, Josep Vidal, Laura Torres‐Collado, Oscar Coltell, Nancy Babio, Javier Hernando‐Redondo, Isabel Moreno‐Indias, Miguel Ruiz‐Canela, Francisco J. Tinahones, Jordi Salas‐Salvadó   +16 more
wiley   +1 more source

Cerveza artesanal: innovaciones biotecnológicas en cervecería y sobre su impacto en la microbiota y salud intestinal

, 2021
Este trabajo ha sido financiado por: Ministerio de Ciencia e Innovación del Gobierno de España Proyecto Retos de Investigación PID2019-108851RB ...
openaire   +2 more sources

Sistematización de experiencias exitosas de desarrollo Rural en el Departamento de Jinotega, 2013 [PDF]

, 2014
Se realizó la investigación titulada “Sistematización de Experiencias Exitosas en Desarrollo Rural en el Departamento de Jinotega, 2013” con el fin de analizar las principales experiencias exitosas que han contribuido al desarrollo rural en este ...
Gonzalez Medrano, Victor Hugo, Mairena Guevara, Humberto Jose, Martinez Lizano, Johana   +2 more
core  

Design, Synthesis, and Evaluation of Naphthyl Pyrazino‐Pyrido‐Pyrimidinones Targeting the Phosphoinositide 3‐Kinase/Alpha‐Serine/Protein Kinase B/Mammalian Target of Rapamycin Pathway

ChemistryOpen, Volume 15, Issue 2, February 2026.
Rationally designed naphthyl pyrazino‐pyrido‐pyrimidinones 3 and 4 inhibited 85%–94% of cancer cell growth. Compound 4 exhibited IC50 = 7.8–12.8 µM with tumor selectivity. Both induced G1 arrest and modulated ULK1, STAT3, alpha‐serine/protein kinase B (AKT), and autophagy via phosphoinositide 3‐kinase/mammalian target of rapamycin (PI3K/mTOR ...
Marcelo F. Marchiori, Gabriel da Silva, Daniel F. Kawano, Andréia M. Leopoldino, Enrique Madruga, Ana Martinez, Ivone Carvalho   +6 more
wiley   +1 more source

Agroindustria y Sistemas de Innovación en Nicaragua [PDF]

, 2014
El artículo explora el desarrollo de la agro industrialización rural, y discursa sobre los distintos enfoques teóricos aplicados en Nicaragua para luego plantear que se requiere un enfoque sistémico a la par de los enfoque de cadenas en sus distintas ...
Lopez, Mario Ramon
core   +3 more sources

Generation of functional noncanonical donor splice sites by +2T variants in breast cancer susceptibility genes: impact on clinical interpretation

The Journal of Pathology, Volume 268, Issue 2, Page 150-163, February 2026.
Abstract Splicing dysregulation is a relevant mechanism of pathogenicity for variants in disease susceptibility genes. Variants affecting the critical intronic +1 and +2 GT nucleotides of the 5’ splice sites (5'ss) are generally strong indicators of pathogenicity.
Inés Llinares‐Burguet, Lara Sanoguera‐Miralles, Elena Bueno‐Martínez, Alicia García‐Álvarez, Alberto Valenzuela‐Palomo, Pedro Pérez‐Segura, Miguel de la Hoya, Eladio A Velasco‐Sampedro   +7 more
wiley   +1 more source

Optimized ACE2‐Fc fusion proteins with picomolar neutralization activity against highly evolved SARS‐CoV‐2 variants

Protein Science, Volume 35, Issue 2, February 2026.
Abstract The rapid evolution of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has compromised the efficacy of many authorized monoclonal antibody products. This highlights the need for alternative strategies, especially for vulnerable populations such as immunocompromised individuals.
Ferran Abancó, Ferran Tarrés‐Freixas, Rosalba Lepore, Elisa Molina‐Molina, Eloi Franco, Rytis Boreika, Edwards Pradenas, Dàlia Raïch‐Regué, Itziar Erkizia, Bonaventura Clotet, Alfonso Valencia, Júlia Vergara‐Alert, Joaquim Segalés, Jorge Carrillo, Nuria Izquierdo‐Useros, Julià Blanco, Benjamin Trinité   +16 more
wiley   +1 more source

Estado actual de la telemedicina: una revisión de literatura

Ingeniare, 2016
La telemedicina es una tecnología que facilita la mediación a distan-cia entre el paciente y el personal médico. Aunque los desarrollos en este campo son más evidentes en Europa y Norte América, en América Latina tendría un mayor impacto, dadas las ...
Erika Yaneth Parrasi Castaño, Lisandro Celis Carvajal, José Joaquín Bocanegra García, Yois Smith Pascuas Rengifo   +3 more
doaj   +1 more source

Private laboratories in pharmaceutical industry: Evolution and merger of capitals [PDF]

, 2013
Durante la última década se implementaron importantes políticas públicas en salud. Se sancionó la Ley de Investigación y Producción Pública de Medicamentos como bienes sociales pero aun no se implementó en el año 2013.
Abrutzky, Rosana, Bramuglia, Cristina, Godio, Cristina de Las M.   +2 more
core  

A Multidomain Lifestyle Intervention Is Associated With Improved Functional Trajectories and Favorable Changes in Epigenetic Aging Markers in Frail Older Adults: A Randomized Controlled Trial

Aging Cell, Volume 25, Issue 2, February 2026.
In frail older adults, a 6‐month lifestyle intervention slowed epigenetic aging and improved functional outcomes, suggesting lifestyle strategies may delay biological aging and disability progression. ABSTRACT Frailty emerges as the intermediate stage preceding disability, but there is a gap in molecular signatures for early detection of subclinical ...
Gloria Olaso‐Gonzalez, Fernando Millan‐Domingo, Luis Garcia‐Fernandez, Elisa Garcia‐Tercero, Monica Cebrian, Cristina Garcia‐Dominguez, Juan Antonio Carbonell, German Casabo‐Valles, Jose Luis Garcia‐Gimenez, Eva Tamayo‐Torres, Juan Gambini, Francisco Jose Tarazona‐Santabalbina, Jose Vina, Maria Carmen Gomez‐Cabrera   +13 more
wiley   +1 more source