Results 101 to 110 of about 3,176,788 (261)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Innovation Policy Report: October 2015
, 2015 The Innovation Policy Report is produced by the Department of Industry, Innovation and Science, and aims to highlight developments in the innovation policy area.
Innovation and Science (Australia) +1 more
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Does Agroindustry matter? An analytical framework of innovation and internationalization process
International Journal of Innovation, 2019 The aim of this work is to develop an analytical framework that explores the relationship between knowledge flows, technological mastery, innovative results & green innovations, organizational growth, internationalization patterns and maturity´s ...
Rafael Kuramoto Gonzalez
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Innovation Policy Report: December 2015
, 2015 The Innovation Policy Report is produced by the Department of Industry, Innovation and Science, and aims to highlight developments in the innovation policy area. It also includes references to relevant innovation documents and events.
Innovation and Science (Australia) +1 more
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Public sector innovation toolkit
, 2016 The Public Sector Innovation Toolkit has been developed to assist individual public servants, public sector teams and agencies who want to increase the extent and effectiveness of their innovation efforts.
Innovation and Science (Australia) +1 more
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
, 2016 Foreword “This is a century of ideas, this is a time when Australia’s growth, when our living standards, when our incomes will be determined by the human capital, the intellectual capital that all of us have. By unleashing our innovation, unleashing our
Innovation and Science (Australia) +1 more
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