Results 101 to 110 of about 46,567 (259)

Digital health technologies and innovation patterns in diabetes ecosystems

Digital Health
Background The global rise in type-2 diabetes (T2D) has prompted the development of new digital technologies for diabetes management. However, despite the proliferation of digital health companies for T2D care, scaling their solutions remains a critical ...
Odile-Florence Giger, Estelle Pfitzer, Wasu Mekniran, Hannes Gebhardt, Elgar Fleisch, Mia Jovanova, Tobias Kowatsch   +6 more
doaj   +1 more source

Targeting Lactate‐Driven Stromal Autophagy via MCT1 Disrupts the Immunosuppressive Niche and Sensitizes Pancreatic Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
Tumor‐derived lactate activates PSCs through MCT1‐mediated Vps34 lactylation and autophagy. These activated PSCs secrete CXCL9/10, upregulating PD‐1 on CD8+ T cells via the CXCR3/STAT3 axis to foster immunosuppression. Disrupting this metabolic crosstalk by targeting MCT1 effectively sensitizes pancreatic cancer to PD‐1 blockade, presenting a promising
Wenfeng Zhuo, Rong Hu, Yuhang Hu, Ping Hu, Shengbo Han, Guozheng Lv, Zhu Zeng, Yong Zhao, Yang Li, Yan Huang, Yingsong Zhao, Hongda Wang, Guangyu Zhao, Eryang Zhao, Gang Zhao   +14 more
wiley   +1 more source

Orchestration competence in innovation ecosystem

Innovation & Management Review
Purpose The paper aims to propose the definition of individual orchestration competence concept and the identification of its main attributes for orchestrating innovation ecosystems. Design/methodology/approach A literature review was conducted ...
Lisiane Machado, Kadígia Faccin, Bruno Anicet Bittencourt   +2 more
openaire   +2 more sources

Unconstrained Coordination of Pt Single Atoms on Distorted g‐C3N4 Enables Electronic Flexibility and Enhanced Microplastics Photoreforming

Advanced Science, EarlyView.
This study reveals Pt single atoms anchored on distorted graphitic carbon nitride, exhibiting flexible coordination and enhanced interfacial charge transfer. Combined spectroscopy and DFT reveal asymmetric Pt─N environments that promote photoreforming of microplastics into hydrogen, demonstrating a solar‐driven pathway for plastic upcycling with ...
Ting‐Han Lin, Yin‐Hsuan Chang, Jia‐Mao Chang, Ciao‐Yun Huang, Kai‐Chi Hsiao, Kuo‐Ping Chiang, Ying‐Han Liao, Kai‐Hsiang Hsu, Jen‐Fu Hsu, Ming‐Chung Wu   +9 more
wiley   +1 more source

A Single‐Cell Transcriptomic Atlas of the Ovine Rumen Microbiome Characterizes Lineage‐Specific Metabolic Shifts Associated with Host Heat Tolerance

Advanced Science, EarlyView.
An optimized single‐cell transcriptomic framework profiles over 60 000 cells to map the ovine rumen microbiome, partitioning the ecosystem into seven cross‐species functional clusters. In heat‐resistant hosts, a lineage‐specific metabolic shift in Anaerovibrio lipolyticus toward a highly glycolytic phenotype contributes to a “nutritional sparing ...
Sanbao Zhang, Qinyang Jiang, Junjie Ma, Jianwei Zou, Fan Wang, Feifei Lv, Yanna Huang, Yongcheng Wang, Ziye Xu   +8 more
wiley   +1 more source

The role science park in augmenting universities’ innovation and commercialization: a bibliometric mapping of past and present research

Cogent Business & Management
This study explores the knowledge structure of university commercialization through science parks. It identifies four major research streams: (1) innovation ecosystems and knowledge transfer, (2) business incubation and entrepreneurial ecosystems, (3 ...
Mohammad Iqbal, Unti Ludigdo, Brillyanes Sanawiri, Rudi Salam, Ari Irawan, Luky Pradita   +5 more
doaj   +1 more source

Thin‐Film Transistor Based Active Taxel for Multimode Tactile Perception and Fused Processing

Advanced Science, EarlyView.
Skin serves as the largest‐area organ for human and embodied intelligent robots, providing tactile interaction. An active multimode fused (AMF) artificial skin is developed using standard TFT processes, featuring 2T‐1C taxels with optical and electrostatic capacitive receptors for cross‐modal sensing.
Sihao Wu, Zheng Zhou, Aoran Xu, Lutong Wang, Tingchen Yi, Chuanlin Sun, Haotong Zhu, Jiaqi Li, Junchen Dong, Li Zhou, Lifeng Liu, Yimao Cai, Dedong Han, Xing Zhang   +13 more
wiley   +1 more source

Knowledge Spillovers and Integrated Circuit Innovation Ecosystem Resilience: Evidence from China

Systems
A resilient innovation ecosystem is an important guarantee for enhancing industrial competitiveness. Knowledge spillover is the key driving force to enhance system resilience.
Shiyu Zhou, Xueguo Xu, Fengmei Liu
doaj   +1 more source

The ecosystem of innovation

Paradigmes: economia productiva i coneixement, 2008
Setting conditions to enhance and to build bridges with entrepreneurs outside the ecosystem of innovation in ...
openaire   +1 more source

Light‐Activated Ruthenium Nanoclusters Reprogram the Metabolic‐Quorum Sensing Axis for Precision Periodontitis Therapy

Advanced Science, EarlyView.
Under 660 nm visible light, Ru NCs efficiently photocatalyze nitrate‐to‐ammonium conversion and modulate oral nitrogen metabolism. They precisely perturb Veillonella parvula, block its key support to Porphyromonas gingivalis, and exert an “inhibiting without killing” antivirulence effect.
Jing Zhou, Xiaolin Sun, Chengyu Liu, Yujia Shi, Meiqi Li, Meng Bo, Jingjie Zhai, Chunyan Li, Zhennan Wu, Xue Bai, Lin Wang   +10 more
wiley   +1 more source