Results 31 to 40 of about 46,567 (259)
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Journal of Open Innovation: Technology, Market and ComplexityShared mobility services – including car-sharing, bike-sharing, and scooter-sharing – have surged in popularity but face persistent challenges. Many providers fail after pilot phases, due not only to technical and managerial issues but also to a ...
Katarzyna Turoń
doaj +1 more source
The complete chloroplast genome sequence of Opuntia sulphurea (Cactaceae)
Mitochondrial DNA. Part B. Resources, 2022 Opuntia sulphurea Gillies ex Salm-Dyck 1834 (Cactaceae) acts as an invasive species due to its ability to survive in various environments. In this study, we assembled the complete chloroplast (cp) genome of Opuntia sulphurea, which was 122,740 bp in ...
Jinyuan Chen +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Energy Reports, 2020 So far, numerous studies have exhibited Silicon Valley and other thriving innovation ecosystems by distinguishing special characteristics in which their survival rely on sustaining activities that convert them to specific regions.
Sedigheh Asefi +2 more
doaj +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Coordination, Complementarity, and Innovativeness in Innovation Ecosystems
Academy of Management Proceedings, 2021 Interdependence and complementarities are two fundamental premises for the existence of innovation ecosystems. Using a computational experiment, we compare the performance of four coordination structures (centralized governance, sequential structure, pooled structure, and coordination by customer choice) in innovation ecosystems under different types ...
Hu, Yimei, Zhang, Huanren, Gao, Yuchen
openaire +3 more sources
Advanced Engineering Materials, EarlyView.This article presents the NFDI‐MatWerk Ontology (MWO), a Basic Formal Ontology‐based framework for interoperable research data management in materials science and engineering (MSE). Covering consortium structures, research data management resources, services, and instruments, MWO enables semantic integration, Findable, Accessible, Interoperable, and ...
Hossein Beygi Nasrabadi +4 more
wiley +1 more source
Co-occurrence of anatoxin-a and microcystins in Lake Garda and other deep subalpine lakes
Advances in Oceanography and Limnology, 2020 Cyanotoxins are a global concern in freshwaters and eutrophication and climate changes can have synergistic effects in exacerbating the problem. Deep Subalpine Lakes (DSL) are a group of lakes of huge economic and naturalistic importance in Italy ...
Leonardo Cerasino, Nico Salmaso
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Integrated Test Sites for Innovation Ecosystems
Technology Innovation Management Review, 2021 Natural test sites are resource-intensive and often limited to single industries or technologies. Drawing upon two strands of research into technology development and innovation strategies, the research question in this paper investigates how converging ...
Michaela Kesselring +4 more
doaj +1 more source